Influence of chronic pain in osteoarthritis on the risk of cardiovascular diseases and modern methods of drug prevention

The purpose of the review of scientific medical literature was to evaluate the data of the epidemiology of osteoarthritis (OA) and cardiovascular diseases (CVD) with the analysis of risk factors, pathophysiological and pathobiochemical mechanisms of the relationship between OA and the risk of develo...

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Published in:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 123; no. 5; p. 20
Main Authors:	Sarvilina, I V, Danilov, Al B, Tkacheva, O N, Gromova, O A, Solovieva, E Yu, Dudinskaya, E N, Rozanov, A V, Kartashova, E A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2023
Subjects:	Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Chondroitin Sulfates Chronic Pain - drug therapy Chronic Pain - epidemiology Chronic Pain - etiology Combined Modality Therapy Humans Osteoarthritis - complications Osteoarthritis - drug therapy Osteoarthritis - epidemiology atherosclerosis chronic pain dorsalgia thromboembolism chondroitin sulfate osteoarthritis cardiovascular risk
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Summary:	The purpose of the review of scientific medical literature was to evaluate the data of the epidemiology of osteoarthritis (OA) and cardiovascular diseases (CVD) with the analysis of risk factors, pathophysiological and pathobiochemical mechanisms of the relationship between OA and the risk of developing CVD in the presence of chronic pain, modern strategies for screening and management of this cohort of patients, the mechanism of action and pharmacological effects of chondroitin sulfate (CS). Conclusions were drawn about the need for additional clinical and observational studies of the efficacy and safety of the parenteral form of CS (Chondroguard) in patients with chronic pain in OA and CVD, improvement of clinical recommendations for the treatment of chronic pain in patients with OA and cardiovascular risk, with special attention to interventions that eliminate mobility restrictions in patients and the inclusion of basic and adjuvant therapy with DMOADs to achieve the goals of multipurpose monotherapy in patients with contraindications to standard therapy drugs.
ISSN:	1997-7298
DOI:	10.17116/jnevro202312305120