Sulfur-containing heterocyclic compounds with potential antidiabetic activity

• Published in: Chimica Techno Acta Vol. 1; no. 3; pp. 83 - 86
• Main Authors: Savateeva, E. A., Emelyanov, V. V., Musalnikova, A. V., Sidorova, L. P., Maksimova, N. E., Machulskaya, N. N., Chereshnev, V. A.
• Format: Journal Article
• Language: English
• Published: Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 31-12-2014
• Subjects: 1,3,4-Тиадиазины; неферментативное гликозилирование белков; противодиабетическая активность; скрининг; структура-активность
• ISSN: 2409-5613; 2411-1414
• DOI: 10.15826/chimtech.2014.1.3.1161

The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction.