Nuclear forms of superoxide dismutase, catalase and peroxidase

Nuclear forms of superoxide dismutase, catalase and peroxidase

Nuclei of rat brain cortex cells contain ownspecific forms of superoxide dismutase (SOD), catalase (CAT) and gluthatione peroxidase (GPx). The enzymes are firmly associated with chromatin, preferationally with transcriptionally active fraction and released from nuclei completely with >1.2 M Nad....

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Bibliographic Details
Published in:Biopolimery i kletka Vol. 12; no. 4; pp. 61 - 64
Main Author: Protas, A. F.
Format: Journal Article
Language:English
Published: Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 1996
Subjects:
Catalase
Chromatin
Chromatofocusing
Enzymes
Ionic strength
Isoelectric points
Oxidation
Peroxidase
Superoxide dismutase
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Summary:Nuclei of rat brain cortex cells contain ownspecific forms of superoxide dismutase (SOD), catalase (CAT) and gluthatione peroxidase (GPx). The enzymes are firmly associated with chromatin, preferationally with transcriptionally active fraction and released from nuclei completely with >1.2 M Nad. Mr of SOD is 10 kDa, CAT and GP× 44 kDa (gel-filtration). Isoelectric points of SOD is under pH 6.0, CAT and GPx 5.8 ( chromatofocusing). The activities of enzymes depend on ionic strength and are maximal under >1.1 MNaCl. Nuclear SOD are not inhibited with KCNand thus, it is MnSOD.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.00043A