Little Things Make Big Things Happen
Objectives: Size, invasion of thoracic structures, and ipsilateral mediastinal lymph node involvement (pN2) are well-known prognostic factors that configure the staging of resectable, locally advanced non–small cell lung cancer (LA-NSCLC). The prognostic impact of angiolymphatic invasion (ALI) and t...
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| Published in: | American journal of clinical pathology Vol. 143; no. 6; pp. 889 - 894 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Oxford University Press
01-06-2015
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| Abstract | Objectives:
Size, invasion of thoracic structures, and ipsilateral mediastinal lymph node involvement (pN2) are well-known prognostic factors that configure the staging of resectable, locally advanced non–small cell lung cancer (LA-NSCLC). The prognostic impact of angiolymphatic invasion (ALI) and tumor necrosis (TN) has been barely explored in LA-NSCLC treated with prior induction therapies.
Methods:
We retrospectively reviewed 47 resected LA-NSCLCs treated with a prior platin-based chemotherapy or chemoradiation. The impact of ALI, TN, and other pathologic features on survival was analyzed.
Results:
ALI was presented in 23.4% of cases and TN in 29.8%. Disease-free and overall survival decreased when ALI, TN, or pN2 was present. The incidence of ALI was lower in LA-NSCLC with a good response to induction.
Conclusion:
Our series is the first to report the prognostic impact of ALI and TN in induction-treated LA-NSCLC. The presence of ALI and TN should be included in the pathologic reports. |
|---|---|
| AbstractList | Objectives:
Size, invasion of thoracic structures, and ipsilateral mediastinal lymph node involvement (pN2) are well-known prognostic factors that configure the staging of resectable, locally advanced non–small cell lung cancer (LA-NSCLC). The prognostic impact of angiolymphatic invasion (ALI) and tumor necrosis (TN) has been barely explored in LA-NSCLC treated with prior induction therapies.
Methods:
We retrospectively reviewed 47 resected LA-NSCLCs treated with a prior platin-based chemotherapy or chemoradiation. The impact of ALI, TN, and other pathologic features on survival was analyzed.
Results:
ALI was presented in 23.4% of cases and TN in 29.8%. Disease-free and overall survival decreased when ALI, TN, or pN2 was present. The incidence of ALI was lower in LA-NSCLC with a good response to induction.
Conclusion:
Our series is the first to report the prognostic impact of ALI and TN in induction-treated LA-NSCLC. The presence of ALI and TN should be included in the pathologic reports. |
| Author | Marquez-Medina, Diego Martin-Marco, Antonio Montero-Fernandez, Angeles Caldero, Sonia Gatius |
| Author_xml | – sequence: 1 givenname: Diego surname: Marquez-Medina fullname: Marquez-Medina, Diego organization: 1Medical Oncology Department, Arnau de Vilanova University Hospital of Lleida, Lleida, Spain – sequence: 2 givenname: Antonio surname: Martin-Marco fullname: Martin-Marco, Antonio organization: 1Medical Oncology Department, Arnau de Vilanova University Hospital of Lleida, Lleida, Spain – sequence: 3 givenname: Sonia Gatius surname: Caldero fullname: Caldero, Sonia Gatius organization: 1Medical Oncology Department, Arnau de Vilanova University Hospital of Lleida, Lleida, Spain – sequence: 4 givenname: Angeles surname: Montero-Fernandez fullname: Montero-Fernandez, Angeles organization: 1Medical Oncology Department, Arnau de Vilanova University Hospital of Lleida, Lleida, Spain |
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| Issue | 6 |
| Keywords | Non–small cell lung cancer Angiolymphatic invasion Mediastinal lymph node involvement Induction treatment Tumor necrosis Locally advanced |
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20180602034923_b26-1430889 article-title: Significance of the presence of microscopic vascular invasion after complete resection of stage I-II pT1-T2N0 non–small cell lung cancer and its relation with T-size categories: did the 2009 7th edition of the TNM staging system miss something? publication-title: J Thorac Oncol doi: 10.1097/JTO.0b013e3182011f70 contributor: fullname: Ruffini |
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Size, invasion of thoracic structures, and ipsilateral mediastinal lymph node involvement (pN2) are well-known prognostic factors that configure... |
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