Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target

• Published in: Journal of radioanalytical and nuclear chemistry Vol. 325; no. 3; pp. 875 - 883
• Main Authors: Ram, Ramu, Chakravarty, Rubel, Jadhav, Sachin, Chakraborty, Sudipta, Jagadeesan, K. C., Thakare, S. V., Dash, Ashutosh
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 2020; Springer Nature B.V
• Subjects: Aluminum oxide; Chemistry; Chemistry and Materials Science; Column chromatography; Diagnostic Radiology; Hadrons; Heavy Ions; Inorganic Chemistry; Nuclear Chemistry; Nuclear Physics; Physical Chemistry; Proton irradiation; Radiochemical separation; Radioisotopes; Rhenium; Rhenium isotopes; Solvent extraction; Sorbents; Tungsten; No-carrier-added; MEK; Re; Mesoporous alumina; Radiopharmaceuticals; Radiochemical separation
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-020-07207-4

Rhenium-186 [
t
½
 = 3.7 d, 1.07 MeV β
−
-particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched
186
W target via
186
W(p, n)
186
Re reaction in a pelletron. A facile radiochemical separation procedure based on selective solvent extraction in methylethyl ketone medium followed by column chromatography using mesoporous alumina sorbent has been developed to obtain
186
Re in a form suitable for radiopharmaceutical preparation. This approach is expected to promote widespread utilization of this radioisotope for the benefit of cancer patients.