BCG vaccine reactivation after mRNA immunization against COVID-19: case report

BCG vaccine reactivation after mRNA immunization against COVID-19: case report

The Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated pathogen vaccine used to prevent severe types of tuberculosis. A related immunological event is its scar reactivation. It is usually associated with Kawasaki disease and the use of other immunizers. In this report, we aim to describe th...

Full description

Saved in:
Bibliographic Details
Published in:Revista médica de Minas Gerais Vol. 33; p. e-33405
Main Authors: José Paulo Ribeiro Júnior, Maria do Carmo Araújo Palmeira Queiroz, Arnoud de Lucena Flor, Clause Willdys Medeiros Dantas
Format: Journal Article
Language:English
Published: Associação Médica de Minas Gerais 01-10-2023
Subjects:
adverse effects
bcg vaccine
covid-19
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract The Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated pathogen vaccine used to prevent severe types of tuberculosis. A related immunological event is its scar reactivation. It is usually associated with Kawasaki disease and the use of other immunizers. In this report, we aim to describe the case of a 24-year-old woman with BCG vaccine scar reactivation after administering a Messenger RNA (mRNA) vaccine against COVID-19, BNT162b2. The pathophysiology involved in the scarring reactivation of the BCG vaccine is related to the chaperone proteins. There are still no cases reported in Brazil of BCG scar reactivation after mRNA vaccines. Nevertheless, we conclude that there is no evidence that such a reaction contraindicates a new dose of the vaccine.
AbstractList The Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated pathogen vaccine used to prevent severe types of tuberculosis. A related immunological event is its scar reactivation. It is usually associated with Kawasaki disease and the use of other immunizers. In this report, we aim to describe the case of a 24-year-old woman with BCG vaccine scar reactivation after administering a Messenger RNA (mRNA) vaccine against COVID-19, BNT162b2. The pathophysiology involved in the scarring reactivation of the BCG vaccine is related to the chaperone proteins. There are still no cases reported in Brazil of BCG scar reactivation after mRNA vaccines. Nevertheless, we conclude that there is no evidence that such a reaction contraindicates a new dose of the vaccine.
Author Clause Willdys Medeiros Dantas
José Paulo Ribeiro Júnior
Maria do Carmo Araújo Palmeira Queiroz
Arnoud de Lucena Flor
Author_xml – sequence: 1
  orcidid: 0000-0001-7394-7586
  fullname: José Paulo Ribeiro Júnior
  organization: Department of Dermatology, University Hospital Onofre Lopes of Federal University of Rio Grande do Norte (UFRN), Rio Grande do Norte, Brazil
– sequence: 2
  orcidid: 0000-0003-0261-9520
  fullname: Maria do Carmo Araújo Palmeira Queiroz
  organization: Department of Dermatology, University Hospital Onofre Lopes of Federal University of Rio Grande do Norte (UFRN), Rio Grande do Norte, Brazil
– sequence: 3
  orcidid: 0000-0002-9372-8660
  fullname: Arnoud de Lucena Flor
  organization: Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil
– sequence: 4
  orcidid: 0000-0003-2935-6740
  fullname: Clause Willdys Medeiros Dantas
  organization: Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil
BookMark eNo9jG1LwzAUhYNMcM79BvsHMm9ymzT126w6B2MDUfFbuU2TkbGmo62C_nrfhufLgefhnHM2im10jF0KmKkc1ZWUaDgKI2cSpHSIKSju4gkb_5sRG4MA5MbA6xmb9v0OvqPBAMgxW98Ui-SdrA3RJZ0jO4R3GkIbE_KD65LmcT1PQtO8xfB55FsKsR-SYvOyvOUiv04s9T_bQ9sNF-zU075302NP2PP93VPxwFebxbKYr7gVGiM3mObCVzVIXQNajbnPBKEylcsVacjQO1U5X2lwFmzmstqgqVMhvDSYa5yw5d9v3dKuPHShoe6jbCmUv6DttiV1Q7B7V1bKUO28rbygFFNNZJVHkdUeK6GMwS9XKmDD
ContentType Journal Article
DBID DOA
DOI 10.5935/2238-3182.2022e33405-en
DatabaseName DOAJ Directory of Open Access Journals
DatabaseTitleList
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: http://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
EISSN 2238-3182
ExternalDocumentID oai_doaj_org_article_b58adefcbf1a4346aac5f317df3b1588
GroupedDBID 91A
ADBBV
ALMA_UNASSIGNED_HOLDINGS
BAWUL
DIK
GROUPED_DOAJ
OK1
ID FETCH-LOGICAL-c163n-83491fbd026d03c639f71a358be95a6073fe5befb60ec0c7e7d838d411f283963
IEDL.DBID DOA
ISSN 0103-880X
IngestDate Tue Oct 22 15:14:21 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c163n-83491fbd026d03c639f71a358be95a6073fe5befb60ec0c7e7d838d411f283963
ORCID 0000-0003-2935-6740
0000-0002-9372-8660
0000-0001-7394-7586
0000-0003-0261-9520
OpenAccessLink https://doaj.org/article/b58adefcbf1a4346aac5f317df3b1588
ParticipantIDs doaj_primary_oai_doaj_org_article_b58adefcbf1a4346aac5f317df3b1588
PublicationCentury 2000
PublicationDate 2023-10-01
PublicationDateYYYYMMDD 2023-10-01
PublicationDate_xml – month: 10
  year: 2023
  text: 2023-10-01
  day: 01
PublicationDecade 2020
PublicationTitle Revista médica de Minas Gerais
PublicationYear 2023
Publisher Associação Médica de Minas Gerais
Publisher_xml – name: Associação Médica de Minas Gerais
SSID ssj0000608002
Score 2.2856731
Snippet The Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated pathogen vaccine used to prevent severe types of tuberculosis. A related immunological event is...
SourceID doaj
SourceType Open Website
StartPage e-33405
SubjectTerms adverse effects
bcg vaccine
covid-19
Title BCG vaccine reactivation after mRNA immunization against COVID-19: case report
URI https://doaj.org/article/b58adefcbf1a4346aac5f317df3b1588
Volume 33
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ25TsQwEIYt2IoGgQBxywWttfH6iE23J0uzSFzaLvKJKAhoDwqennEcEFQ0tC6sJBN7vrFn_kHoAhhecGki0Q7wjZcFJ1pyRyKVvSAktzqmA7fpXTmbq9E4yeR8t_pKOWFZHjh_uK4VyvgQnY3UcAbTGiciOD0fmaVC5TLfQv0IpvIe3JBQk79YMAI_6TwndwnNRBdcYjoUVKkQq9cLjAG1kFD_ku1v_MtkB223YIj7-YF20Uao99BsMLzC78al228MeOe-mpHhprc3frmd9fFzU-Lx0Y4_Qai_XOHhzeP1iFB9iR34KZyvBvbRw2R8P5yStgMCccBJNVGMaxqth0DJF8wBTcSSGiaUDVoYCcszBmFDtLIIrnBlKL1iynNKI2ADrK0D1Klf63CIsPLRQjRigAg4LzVVwYtgolTSJFk4f4QG6eWrtyxyUSXZ6WYAjFG1xqj-Msbxf0xygrZST_ecMXeKOqvFOpyhzaVfnzdG_gTwG6lu
link.rule.ids 315,782,786,866,2108,27935,27936
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=BCG+vaccine+reactivation+after+mRNA+immunization+against+COVID-19%3A+case+report&rft.jtitle=Revista+m%C3%A9dica+de+Minas+Gerais&rft.au=Jos%C3%A9+Paulo+Ribeiro+J%C3%BAnior&rft.au=Maria+do+Carmo+Ara%C3%BAjo+Palmeira+Queiroz&rft.au=Arnoud+de+Lucena+Flor&rft.au=Clause+Willdys+Medeiros+Dantas&rft.date=2023-10-01&rft.pub=Associa%C3%A7%C3%A3o+M%C3%A9dica+de+Minas+Gerais&rft.issn=0103-880X&rft.eissn=2238-3182&rft.volume=33&rft.spage=e-33405&rft_id=info:doi/10.5935%2F2238-3182.2022e33405-en&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_b58adefcbf1a4346aac5f317df3b1588
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0103-880X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0103-880X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0103-880X&client=summon