Can Designer Indels Be Tailored by Gene Editing?

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could b...

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Bibliographic Details
Published in:	BioEssays Vol. 41; no. 12
Main Authors:	Trimidal, Sara G., Benjamin, Ronald, Bae, Ji Eun, Han, Mira V., Kong, Elizabeth, Singer, Aaron, Williams, Tyler S., Yang, Bing, Schiller, Martin R.
Format:	Journal Article
Language:	English
Published:	Cambridge Wiley Subscription Services, Inc 01-12-2019
Subjects:	Binding CRISPR/Cas9 Deoxyribonucleic acid DNA DNA damage DNA repair double strand break gene editing Gene expression Genetic modification Genomes Insertion Literature reviews Maintenance meganuclease Non-homologous end joining Nuclease TALEN Therapeutic applications zinc finger nuclease
Online Access:	Get full text
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