Clinical and functional evaluation of efficiency in the treatment of macular edema associated with thrombosis of the central retinal vein and its branches

• Published in: Oftalʼmokhirurgii͡a︡ = Ophthalmosurgery no. 3; pp. 56 - 62
• Main Authors: Kamenskikh, T.G., Batishcheva, Y.S., Gileva, E.V., Kolbenev, I.O.
• Format: Journal Article
• Language: English; Russian
• Published: Publishing house "Ophthalmology" 01-11-2019
• Subjects: angio-oct; perfusion density; thrombosis of the central retinal vein and its branches; vascular density
• ISSN: 0235-4160; 2312-4970
• DOI: 10.25276/0235-4160-2019-3-56-62

Purpose. An assessment of the efficacy of a prolonged corticosteroid and anti-VEGF therapy in the treatment of macular edema with thrombosis of the central retinal vein and its branches.Material and methods. In the study there were examined 77 patients: 38 females and 39 males (77 eyes) with the aftereffects of thrombosis of the central retinal vein and its branches. Patients were divided into three groups, depending on the performed treatment: the group I (25 eyes) – intravitreal injections of ranibizumab (Lucentis), the group II (26 eyes) – intravitreal injections of aflibercept (Eilea), the group III (26 eyes) – intravitreal injections of Ozurdex. Patients underwent the standard ophthalmologic examination, optical coherence tomography (OCT), optical coherent angiotomography, and multifocal ERG.Results. The effect of intravitreal injections of angiogenesis inhibitors and a dexamethasone implant was significant in all groups. A more pronounced positive effect had the drug Ozurdex. The duration of the therapeutic effect was evaluated in these groups of patients. In the groups I and II, the thickness of the retina began to increase by the end of the first month after the third injection in 78.1 and 71.4% of patients, respectively. In the group III this effect was by the end of the third month – in 11.8%, by the end of the fourth month – in 35.3%, that is, the positive effect was longer in patients receiving Ozurdex. Intravitreal injection of dexamethasone implant has no negative impact on the density parameters of the superficial retinal vascular plexus.Conclusion. The use of anti-VEGF therapy and an intravitreal dexamethasone implant are effective in patients with macular edema in case of retinal vein thrombosis occlusion. A longer positive effect of the performed therapy was observed in patients who underwent intravitreal administration of a dexamethasone implant.