Pharmacological Properties of 2-Aminobenzimidazole Halides and Imidazo[1,2-a]Benzimidazole Derivatives

• Published in: Russian journal of bioorganic chemistry Vol. 48; no. 2; pp. 281 - 291
• Main Authors: Spasov, A. A., Zhukovskaya, O. N., Gurova, N. A., Naumenko, L. V., Eliseeva, N. V., Kucheryavenko, A. F., Kosolapov, V. A., Yakovlev, D. S., Muravyeva, V. Y., Babkova, V. A., Babkov, D. A., Lifanova, J. V., Morkovnik, A. S.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2022; Springer Nature B.V
• Subjects: Aminobenzimidazole; Antioxidants; Biochemistry; Biological activity; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Halides; Life Sciences; Organic Chemistry; Refractory period; imidazo[1,2; benzimidazole; NHE-1 inhibitory activity; antiplatelet action; 2-aminobenzimidazolium halides; antiglycating effect; hemorheological activity
• ISSN: 1068-1620; 1608-330X
• DOI: 10.1134/S1068162022020236

Halides of 2-aminobenzimidazolium and derivatives of 9-substituted 2-(4-fluorophenyl)imidazo[1,2-
a
]benzimidazoles have been studied for ten types of biological activity in vitro. Among the aminobenzimidazolium derivatives, a compound with NHE-1 inhibitory activity has been identified. It has been demonstrated that imidazobenzimidazole derivatives affect the duration of the refractory period of rat atria, platelet aggregation, and hemorheological activity and inhibit the formation of end products of glycation. No DPP-4 inhibitory, antioxidant, kappa-opioid, and 5-HT
2A
and 5-HT
3
antagonistic activities have been found among the studied compounds.