Influence of Anatomic Locations of T1b Melanomas and Patient Age on Outcomes

• Published in: Journal of drugs in dermatology Vol. 23; no. 5; p. 306
• Main Authors: Huang, Margaret Y, Chen, Alessandra, Quarshie, Claudia, Masson, Rahul, Barajas, Gabrielle, Kim, Gene, DeClerck, Brittney, Swanson, Mark S, In, Gino K, Kokot, Niels, Pickering, Trevor A, Hu, Jenny C
• Format: Journal Article
• Language: English
• Published: United States 01-05-2024
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Female; Humans; Los Angeles - epidemiology; Lymphatic Metastasis - diagnosis; Male; Melanoma - diagnosis; Melanoma - epidemiology; Melanoma - pathology; Middle Aged; Neoplasm Staging; Retrospective Studies; Sentinel Lymph Node Biopsy; Skin Neoplasms - diagnosis; Skin Neoplasms - epidemiology; Skin Neoplasms - pathology; Young Adult; Los Angeles
• ISSN: 1545-9616
• DOI: 10.36849/JDD.7667

There are no guidelines on when to more strongly recommend sentinel lymph node biopsy (SLNB) for T1b melanomas.
To examine whether anatomic locations of T1b melanomas and patient age influence metastases.
We conducted a retrospective study using data from two hospitals in Los Angeles County from January 2010 through January 2020.
Out of 620 patients with primary melanomas, 566 melanomas were staged based on the American Joint Committee on Cancer 8th edition melanoma staging. Forty-one were T1b, of which 13 were located on the face/ear/scalp and 28 were located elsewhere. T1b melanomas located on the face/ear/scalp had an increased risk of lymph node or distant metastasis compared with other anatomic sites (31% vs 3.6%, P=0.028). For all melanomas, the risk of lymph node or distant metastasis decreased with age of 64 years or greater (P<0.001 and P=0.034). For T1b melanomas, the risk of distant metastasis increased with increasing age (P=0.047).
Data were from a single county. Conclusion: T1b melanomas of the face/ear/scalp demonstrated a higher risk of lymph node or distant metastasis and may help guide the recommendation of SLNB, imaging, and surveillance. Younger patients may be more strongly considered for SLNB and older patients with T1b melanomas may warrant imaging. J Drugs Dermatol. 2024;23(5):306-310. doi:10.36849/JDD.7667.