Intravenous magnesium sulfate as a preanesthetic medication: A double-blind study on its effects on hemodynamic stabilization at the time of tracheal intubation

• Published in: Journal of anesthesia Vol. 8; no. 1; pp. 17 - 20
• Main Authors: Kagawa, Tetsuro, Goto, Ryokichi, Iijima, Katsuhiro, Kamikawa, Yuji, Sakai, Keiichi, Obara, Hidefumi
• Format: Journal Article
• Language: English
• Published: Japan 01-03-1994
• Subjects: Preanesthetic medication; Magnesium; Intratracheal intubation
• ISSN: 0913-8668; 1438-8359
• DOI: 10.1007/BF02482746

The effects of magnesium sulfate (MgSO
) as a preanesthetic medication were studied with regard to whether it can sedate or relieve a patient who is scheduled to undergo surgery, and whether it can control the hemodynamic response to tracheal intubation. Twenty adult patients in ASA status 1-2 undergoing elective surgery were studied. Ten patients received 50 mg·g
MgSO
intravenously by drip infusion from 30 min before the induction of anesthesia, and another ten patients received saline as a control. The changes in mean arterial pressure (MAP) and rate pressure product (RPP) after the intubation were significantly suppressed in magnesium-treated patients, but a sedative effect was not observed. Therefore, MgSO
was useful as a preanesthetic medication in suppressing the hemodynamic response associated with tracheal intubation.