Tegretol (Carbamazepine) effect on the morphometric assay of liver in female white mice (Mus musculus)

• Published in: Ibn Al-Haitham Journal for Pure and Applied Sciences Vol. 31; no. 3; pp. 1 - 9
• Main Authors: Jabir, Nawar R., al-Bakri, Nahlah Abd al-Rida
• Format: Journal Article
• Language: English
• Published: Baghdad, Iraq University of Baghdad, College of Education for Pure Science / Ibn al-Haitham 13-11-2018; University of Baghdad
• Subjects: Carbamazepine, Liver, Morphometric assay
• DOI: 10.30526/31.3.1997
• EISSN: 2521-3407
• ISSN: 1609-4042

Carbamazepine (CBZ) is one of many anticonvulsants used to treat trigeminal neuralgia
and epilepsy. Antiepileptic drugs (AED`s) are the second most important class of medications
that lead to hepatotoxicity and induced liver injury, this study was conducted to evaluate the
effects of CBZ on the liver. A total of 40 female mice were taken and divided into four groups
(A/treated for 14 days, B/ control, C/ treated for 30 days, D/ control), the drug was given as an
oral suspension formula 100mg/5ml at dose 20 mg/kg/mouse via gastric gavage daily for 14
and 30 days. Statistical analysis revealed that there were no significant differences in the
white female mice body weight (P>0.05) in the treated group for 14 days as well as the treated
group for 30 days, but there were significant differences between the treated groups studied.
Statistical analyses result of liver weight, hepatocytes diameter, central vein and portal vein
diameters showed significant differences in the treated group for 14 days (P<0.05) as well as
the treated group for 30 days, and there were significant differences between all treated
groups studied. The study concluded that carbamazepine (CBZ) can had no effect on body
weight but it can induce several hepatic changes if it used on a short or long terms, therefore,
it was advised to take cautions when describing this drug.-