The BACE ‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease

The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti‐Aβ therapies in dementia stages sug...

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Bibliographic Details
Published in:	EMBO molecular medicine Vol. 10; no. 11
Main Authors:	Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina
Format:	Journal Article
Language:	English
Published:	Frankfurt EMBO Press 01-11-2018
Subjects:	Aging Alzheimer's disease Amyloid precursor protein Animal models Cerebrospinal fluid Clinical trials Dementia Dementia disorders Disease prevention Liver Neurodegeneration Neurodegenerative diseases Patients Pharmacodynamics Retina Toxicity Transgenic animals Transgenic mice β-Site APP-cleaving enzymes Switzerland Ireland
Online Access:	Get full text
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