Predictive Value of the sFlt-1: PlGF Ratio in Women With Suspected Preeclampsia

• Published in: Obstetric anesthesia digest Vol. 36; no. 3; pp. 145 - 146
• Main Authors: Zeisler, H, Llurba, E, Chantraine, F, Vatish, M, Cathrine Staff, A, Sennström, M, Olovsson, M, Brennecke, S.P, Stepan, H, Allegranza, D, Dilba, P, Schoedl, M, Hund, M, Verlohren, S
• Format: Journal Article
• Language: English
• Published: Copyright Wolters Kluwer Health, Inc. All rights reserved 01-09-2016
• DOI: 10.1097/01.aoa.0000489468.07157.ab
• EISSN: 1536-5395
• ISSN: 0275-665X

(N Engl J Med. 2016;374:13–22)Preeclampsia is a serious multisystem disorder affecting up to 5% of pregnancies worldwide. A reliable predictor of preeclampsia would be helpful in allowing health care providers to identify women at risk for developing the disorder. Serum levels of circulating maternal soluble fms-like tyrosine kinase 1 (sFlt-1) are known to be elevated in preeclampsia, while levels of placental growth factor (PlGF) are decreased. A high ratio of sFlt-1 to PlGF indicates an increased risk for preeclampsia and could potentially be a more reliable predictor than either of those factors alone. The authors of this study sought to evaluate the ratio as a predictive tool among women with suspected preeclampsia.