Neurotoxic glutamate treatment of cultured cerebellar granule cells induces Ca 2+-dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria
Rhodamine 123 staining and electron microscopy were used to reveal a correlation between the ultrastructural and functional state of cultured cerebellar granule cells after short glutamate treatment. Glutamate exposure (15 min, 100 μM) in Mg 2+-free solution caused considerable ultrastructural alter...
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| Published in: | FEBS letters Vol. 392; no. 2; pp. 143 - 147 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
26-08-1996
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| Abstract | Rhodamine 123 staining and electron microscopy were used to reveal a correlation between the ultrastructural and functional state of cultured cerebellar granule cells after short glutamate treatment. Glutamate exposure (15 min, 100 μM) in Mg
2+-free solution caused considerable ultrastructural alterations in a granule cell: clumping of the chromatin, swelling of the endoplasmic reticulum and mitochondria, and disruption of the mitochondrial cristae. After glutamate treatment, the mitochondria of the neurons lost their ability to sequester rhodamine 123. Both the
N-
ethyl-
d-aspartate
receptor channel blocker MK-801 (30 μM) and cobalt chloride (2 mM) prevented the deteriorative effects of glutamate. These data suggest that glutamate-induced Ca
2+ overload of the neurons can lead to non-specific permeability of the inner mitochondrial membrane, resulting in neuronal death. |
|---|---|
| AbstractList | Rhodamine 123 staining and electron microscopy were used to reveal a correlation between the ultrastructural and functional state of cultured cerebellar granule cells after short glutamate treatment. Glutamate exposure (15 min, 100 μM) in Mg
2+-free solution caused considerable ultrastructural alterations in a granule cell: clumping of the chromatin, swelling of the endoplasmic reticulum and mitochondria, and disruption of the mitochondrial cristae. After glutamate treatment, the mitochondria of the neurons lost their ability to sequester rhodamine 123. Both the
N-
ethyl-
d-aspartate
receptor channel blocker MK-801 (30 μM) and cobalt chloride (2 mM) prevented the deteriorative effects of glutamate. These data suggest that glutamate-induced Ca
2+ overload of the neurons can lead to non-specific permeability of the inner mitochondrial membrane, resulting in neuronal death. Rhodamine 123 staining and electron microscopy were used to reveal a correlation between the ultrastructural and functional state of cultured cerebellar granule cells after short glutamate treatment. Glutamate exposure (15 min, 100 μM) in Mg 2+ ‐free solution caused considerable ultrastructural alterations in a granule cell: clumping of the chromatin, swelling of the endoplasmic reticulum and mitochondria, and disruption of the mitochondrial cristae. After glutamate treatment, the mitochondria of the neurons lost their ability to sequester rhodamine 123. Both the N ‐methyl‐ d ‐aspartate receptor channel blocker MK‐801 (30 μM) and cobalt chloride (2 mM) prevented the deteriorative effects of glutamate. These data suggest that glutamate‐induced Ca 2+ overload of the neurons can lead to non‐specific permeability of the inner mitochondrial membrane, resulting in neuronal death. |
| Author | Zorov, Dmitry B. Stelmashook, Elena V. Uzbekov, Rustem E. Isaev, Nikolaj K. Victorov, Ilya V. Kozhemyakin, Maxim B. |
| Author_xml | – sequence: 1 givenname: Nikolaj K. surname: Isaev fullname: Isaev, Nikolaj K. organization: Brain Research Institute, Russian Academy of Medical Sciences, p. Obuha 5, 103064, Moscow, Russian Federation – sequence: 2 givenname: Dmitry B. surname: Zorov fullname: Zorov, Dmitry B. organization: A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 117292, Moscow, Russian Federation – sequence: 3 givenname: Elena V. surname: Stelmashook fullname: Stelmashook, Elena V. organization: Brain Research Institute, Russian Academy of Medical Sciences, p. Obuha 5, 103064, Moscow, Russian Federation – sequence: 4 givenname: Rustem E. surname: Uzbekov fullname: Uzbekov, Rustem E. organization: A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 117292, Moscow, Russian Federation – sequence: 5 givenname: Maxim B. surname: Kozhemyakin fullname: Kozhemyakin, Maxim B. organization: Brain Research Institute, Russian Academy of Medical Sciences, p. Obuha 5, 103064, Moscow, Russian Federation – sequence: 6 givenname: Ilya V. surname: Victorov fullname: Victorov, Ilya V. organization: Brain Research Institute, Russian Academy of Medical Sciences, p. Obuha 5, 103064, Moscow, Russian Federation |
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| Keywords | GLU MK-801 Mitochondria Neurotoxicity Ultrastructure R123 NMDA Membrane potential Cytosolic Ca 2 Glutamate BSM |
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| SubjectTerms | Cytosolic Ca 2 Glutamate Membrane potential Mitochondria Neurotoxicity Ultrastructure |
| Title | Neurotoxic glutamate treatment of cultured cerebellar granule cells induces Ca 2+-dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria |
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