Protein Interaction Assessing Mitochondrial Biogenesis as a Next Generation Biomarker in Sepsis

Metabolic derangements in sepsis stem from mitochondrial injury and contribute to organ dysfunction and mortality. Thus, repair of mitochondrial damage seems pivotal for recovery and determining clinical outcome in sepsis. However, reliable biomarkers assessing mitochondrial repair noninvasively in...

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Bibliographic Details
Published in:	CHEST critical care Vol. 2; no. 2; p. 100065
Main Authors:	Thon, Patrick, Trübner, Ellen, Zimmer, Frieda, Palmowski, Lars, Ehrentraut, Stefan F., Putensen, Christian, Henzler, Dietrich, Schwier, Elke, Witowski, Andrea, Marko, Britta, Ziehe, Dominik, Nowak, Hartmuth, Rump, Katharina, Bergmann, Lars, Wolf, Alexander, Unterberg, Matthias, Adamzik, Michael, Koos, Björn, Rahmel, Tim, Adamzik, Stephanie, Bazzi, Maha, von Busch, Alexander, Haberl, Helge, Rahmel, Barbara, Willemsen, Katrin, Zuelch, Birgit, Anft, Moritz, Babel, Nina, Annecke, Thorsten, Defosse, Jerome M., Limper, Ulrich, Wappler, Frank, Bode, Christian, Schewe, Jens-Christian, Bracht, Thilo, Sitek, Barbara, Eisennacher, Martin, Kleefisch, Daniel, Marcus, Katrin, Ellger, Björn, Oswald, Daniel, Ertmer, Christian, Zarbock, Alexander, Frey, Ulrich H., Fuchs, Katrin, Köhler, Thomas
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-06-2024
Subjects:	mitochondrial biogenesis mitochondrial damage clearance mitochondrial transcription factor A protein interaction sepsis protein interaction PLA mtDNA mRNA NRF1 TFB2M mitochondrial biogenesis PBMC SOFA mitochondrial damage clearance TFAM mitochondrial transcription factor A sepsis MQC
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