A research for some oxazolidinones to evaluate their antimicrobial activity

A research for some oxazolidinones to evaluate their antimicrobial activity

Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231. Material and Method: Form...

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Bibliographic Details
Published in:Ankara Üniversitesi Eczacılık Fakültesi dergisi = Journal of Faculty of Pharmacy of Ankara University Vol. 42; no. 3; pp. 32 - 37
Main Authors: Kuş,Canan, Uğurlu,Ezgi, Altanlar,Nurten
Format: Journal Article
Language:English
Published: Ankara Üniversitesi Eczacılık Fakültesi 01-03-2018
Subjects:
Sağlık Hizmetleri
Tıp
Ankara
Türkiye
oxazolidinon
linezolid
oksazolidinon
antimicrobial activity
antimikrobiyal aktivite
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Summary:Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231. Material and Method: Formerly obtained and published 10 oxazolidinones were tested against antimicrobial activity and this evaluation was carried out in Mueller-Hinton broth and Sabouraud dextrose broth. Result and Discussion: Compounds E5, and E9 showed antimicrobial activity against both bacteria and fungi with 25 μg/mL and 50 μg/mL, respectively. Our present research and the others have shown that the electro-negativity degree is very important for the biological activity.
ISSN:1015-3918
DOI:10.1501/Eczfak_0000000610