Total pancreatectomy for pancreatic cancer

• Published in: Hirurgija (Moskva) no. 9; p. 13
• Main Authors: Patyutko, Yu I, Kudashkin, N E, Kotel'nikov, A G, Chistyakova, O V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2016
• Subjects: Female; Humans; Long Term Adverse Effects - diagnosis; Long Term Adverse Effects - etiology; Long Term Adverse Effects - prevention & control; Long Term Adverse Effects - psychology; Male; Metabolic Diseases - diagnosis; Metabolic Diseases - etiology; Middle Aged; Moscow - epidemiology; Neoplasm Staging; Pancreatectomy - adverse effects; Pancreatectomy - methods; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - surgery; Postoperative Complications - diagnosis; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Postoperative Complications - psychology; Quality of Life; Retrospective Studies; Survival Analysis; Treatment Outcome
• ISSN: 0023-1207
• DOI: 10.17116/hirurgia2016913-20

to determine the indications and to evaluate early and long-term outcomes of total pancreatectomy for pancreatic cancer.
Treatment of 29 patients who underwent one- and two-stage pancreatectomy for different malignancies was analyzed.
Median of surgery duration and intraoperative blood loss was 280 min and 2200 ml respectively. Postoperative complications were observed in 9 (31%) patients. There were 2 (6.9%) deaths. 1- and 3-year overall actual survival was 61% and 16% respectively in case of ductal adenocarcinoma. Median was 18 months. Patients after surgery for primary multiple lesion (cancer of pancreatic body-tail and major duodenal papilla), pancreatic metastases of renal cancer, mucinous cystadenoma and neuroendocrine cancer are still alive. Follow-up periods are 4, 49, 49 and 65 months respectively.
Total pancreatectomy is difficult intervention followed by severe metabolic disorders. However it can improve long-term survival with acceptable incidence of postoperative complications and quality of life if clear indications for surgery are present.