RELATIONSHIP BETWEEN RESIDUAL DIURESIS AND SARCOPENIA IN PATIENTS ON HEMODIALYSIS

• Published in: Journal of renal nutrition
• Main Authors: Rodrigues, Vanessa Gomes Brandão, Silva, Whesley Tanor, da Silva, Ana Caiane Rocha, Campos, Patrícia Cardoso, Santos, Luciana Martins de Mello, Lacerda, Ana Cristina Rodrigues, Alves, Frederico Lopes, Maciel, Emílio Henrique Barroso, Prates, Maria Cecília Sales Mendes, Costa, Henrique Silveira, de Lima, Vanessa Pereira, Mendonça, Vanessa Amaral, Figueiredo, Pedro Henrique Scheidt
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22-06-2024
• Subjects: chronic kidney disease; hemodialysis; kidney disease; muscle function; residual diuresis; hemodialysis; kidney disease; chronic kidney disease; muscle function; residual diuresis
• ISSN: 1051-2276; 1532-8503; 1532-8503
• DOI: 10.1053/j.jrn.2024.06.006

To assess the association of residual diuresis with sarcopenia in patients with Chronic Kidney Disease (CKD) on hemodialysis.
Through a cross-sectional study, patients on hemodialysis were subjected to a Dual Energy Radiologic Absorption (DEXA) exam to record muscle mass. Based on the volume of urine collected in 24 hours, patients were classified as anuric (diuresis ≤ 100 mL/day) or non-anuric (diuresis > 100 mL/day). Functional performance was evaluated by Short Physical Performance Battery (SPPB) and muscle strength by handgrip strength and 5-repetition sit-to-stand test. The association between the absence of residual urine and the presence of sarcopenia, low SPPB, and low muscle strength was analyzed using a binary logistic regression model.
Ninety-two patients, with a mean age of 54.4 years (95% CI 51.3 – 57.4) and with a mean diuresis volume of 476.3 mL/day (95% CI 320.4 – 632.2) were evaluated (48 anuric and 44 non-anuric). Anuric patients had a 2.77 (95% CI 1.14 – 6.73) times greater probability of sarcopenia and had a 3.55 (1.14 – 11.0) times greater probability of low SPPB, regardless of gender, age, and time on dialysis. Gender was the other associated variable for the presence of sarcopenia, with males having a 3.30 (95% CI 1.34 – 8.13) times higher risk. There were no associations with muscle strength.
The absence of residual diuresis in patients on hemodialysis is associated with a higher risk of sarcopenia and low functional performance.