Coumarin (2H-1-Benzopyran-2-one) act against planktonic and biofilm forms of Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa

• Published in: Revista colombiana de ciencias químico-farmacéuticas Vol. 50; no. 3
• Main Authors: Vilar Cordeiro, Laísa, Da Silva Souza, Helivaldo Diógenes, da Silva Sá, Giulian César, Pereira Sousa, Aleson, De Figueiredo, Thiago Ramalho, das Neves Silva Neta, Maria, Barbosa Filho, José Maria, de Oliveira Lima, Edeltrudes
• Format: Journal Article
• Language: English
• Published: Bogota Universidad Nacional de Colombia 2021
• Subjects: Biofilms; Coumarin; Klebsiella; Penicillin; Pharmacology; Pseudomonas aeruginosa; Staphylococcus infections
• ISSN: 0034-7418; 1909-6356
• DOI: 10.15446/rcciquifa.v50n3.100226

Introduction: biofilm-related infections caused by Staphylococcus aureus, Klebsi-ella pneumoniae and Pseudomonas aeruginosa are difficult to treat and few effective pharmacological options are currently available for this purpose. In this context, coumarin (2H-1-Benzopyran-2-one) has been reported to have antibacterial and antibiofilm activity, but this potential remains poorly understood. Aim: to investi-gate the action of coumarin on planktonic and biofilm forms of S. aureus, K. pneu-moniae and P. aeruginosa. Results: a minimum inhibitory concentration (MIC) of coumarin ranging from 256 to 1024 μg/mL was observed, with a remarkable ability to inhibit the formation of biofilms and to act on mature biofilms in concentrations close to MIC. Conclusion: coumarin has strong activity against planktonic and biofilm forms on the three species of great relevance in the clinical scenario. These results are interesting to enable a pharmacological alternative for the treatment of these infections.