Production of 52Fe from symmetric complete fusion-evaporation reactions
A promising method for the production and extraction of 52Fe utilizing near-symmetric, heavy-ion fusion-evaporation reactions is presented. A 28Si beam was used to bombard a 27Al target, producing 52Fe through the reaction: 27Al (28Si, p2n)52Fe. After irradiation, the aluminum target was dissolved,...
Saved in:
| Published in: | Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Vol. 493; pp. 15 - 18 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier B.V
15-04-2021
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | A promising method for the production and extraction of 52Fe utilizing near-symmetric, heavy-ion fusion-evaporation reactions is presented. A 28Si beam was used to bombard a 27Al target, producing 52Fe through the reaction: 27Al (28Si, p2n)52Fe. After irradiation, the aluminum target was dissolved, and the 52Fe was separated from the aluminum matrix and other reaction products through the use of a cationic-exchange column. It was possible to recover the 52Fe (t1/2 = 8.3 h) with high specific activity, higher than can be achieved with the high energy proton spallation reactions currently used to produce this isotope, which has significance in medical research. The production yields for this reaction were measured and compared to PACE4 calculations. These results demonstrate the potential for dedicated accelerator production of 52Fe using heavy-ion beams, which will result in higher specific activities with robust radiochemical purification techniques. |
|---|---|
| AbstractList | A promising method for the production and extraction of 52Fe utilizing near-symmetric, heavy-ion fusion-evaporation reactions is presented. A 28Si beam was used to bombard a 27Al target, producing 52Fe through the reaction: 27Al (28Si, p2n)52Fe. After irradiation, the aluminum target was dissolved, and the 52Fe was separated from the aluminum matrix and other reaction products through the use of a cationic-exchange column. It was possible to recover the 52Fe (t1/2 = 8.3 h) with high specific activity, higher than can be achieved with the high energy proton spallation reactions currently used to produce this isotope, which has significance in medical research. The production yields for this reaction were measured and compared to PACE4 calculations. These results demonstrate the potential for dedicated accelerator production of 52Fe using heavy-ion beams, which will result in higher specific activities with robust radiochemical purification techniques. |
| Author | McGuinness, Sean R. Henderson, Samuel L. Lapi, Suzanne E. Ferran, Samuel J. Loveless, C. Shaun Wilkinson, John T. Blankstein, Drew Skulski, Michael Peaslee, Graham F. Clark, Adam M. Reingold, Craig S. Nelson, Austin D. Anderson, Tyler |
| Author_xml | – sequence: 1 givenname: Sean R. surname: McGuinness fullname: McGuinness, Sean R. email: smcguinn@nd.edu organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 2 givenname: Samuel J. surname: Ferran fullname: Ferran, Samuel J. organization: Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States – sequence: 3 givenname: John T. surname: Wilkinson fullname: Wilkinson, John T. organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 4 givenname: C. Shaun surname: Loveless fullname: Loveless, C. Shaun organization: Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States – sequence: 5 givenname: Tyler surname: Anderson fullname: Anderson, Tyler organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 6 givenname: Drew surname: Blankstein fullname: Blankstein, Drew organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 7 givenname: Adam M. surname: Clark fullname: Clark, Adam M. organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 8 givenname: Samuel L. surname: Henderson fullname: Henderson, Samuel L. organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 9 givenname: Austin D. surname: Nelson fullname: Nelson, Austin D. organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 10 givenname: Craig S. surname: Reingold fullname: Reingold, Craig S. organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 11 givenname: Michael surname: Skulski fullname: Skulski, Michael organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States – sequence: 12 givenname: Suzanne E. surname: Lapi fullname: Lapi, Suzanne E. organization: Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States – sequence: 13 givenname: Graham F. surname: Peaslee fullname: Peaslee, Graham F. organization: Department of Physics, University of Notre Dame, Notre Dame, IN 46556, United States |
| BookMark | eNp9kNFKwzAUhoNMcJu-gFd9gdaTpGlS8EaGm8JALxS8C2l6ChlrM5JusLc33bz23Pxw-L_D4VuQ2eAHJOSRQkGBVk-7YnB9UzBgtABWAKgbMqdKsrwWqpyReSqpXCj-c0cWMe4gjeBiTjafwbdHOzo_ZL7LBFtj1gXfZ_Hc9zgGZzPr-8Mex7Q_xlTL8WQOPpgLEtBc2HhPbjuzj_jwl0vyvX79Wr3l24_N--plm1taCpVzpLICLJtWycooibWsKywV7WqgpoaqEXULTdN2DCUzVdlwVXFqOCCn0pZ8Sdj1rg0-xoCdPgTXm3DWFPSkQu_0pEJPKjQwnVQk6PkKYfrs5DDoaB0OFlsX0I669e4__Bcy9mmB |
| CitedBy_id | crossref_primary_10_1016_j_apradiso_2021_109935 crossref_primary_10_1038_s41598_021_94922_x |
| Cites_doi | 10.1002/gps.2640 10.1046/j.1365-2141.2003.03590.x 10.1016/j.nimb.2015.04.025 10.1016/0003-2670(56)80137-2 10.1046/j.1365-2141.1999.01170.x 10.1016/0020-708X(70)90081-5 10.1103/PhysRevC.21.230 10.1186/s40658-016-0144-5 10.1524/ract.1972.18.2.108 10.1016/0883-2889(90)90197-O 10.1016/j.nimb.2008.05.110 10.3390/app3030593 10.1016/j.nimb.2010.02.091 10.1634/theoncologist.12-12-1379 10.2217/fon.14.139 |
| ContentType | Journal Article |
| Copyright | 2021 Elsevier B.V. |
| Copyright_xml | – notice: 2021 Elsevier B.V. |
| DBID | AAYXX CITATION |
| DOI | 10.1016/j.nimb.2021.02.008 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Physics |
| EISSN | 1872-9584 |
| EndPage | 18 |
| ExternalDocumentID | 10_1016_j_nimb_2021_02_008 S0168583X21000732 |
| GroupedDBID | --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 5VS 7-5 71M 8P~ 9JN AABNK AABXZ AACTN AAEDW AAEPC AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABMAC ABNEU ABXRA ABYKQ ACDAQ ACFVG ACGFS ACRLP ADEZE AEBSH AEKER AEZYN AFKWA AFRZQ AFTJW AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AIVDX AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM LZ4 M41 MAGPM MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RNS ROL RPZ SDF SDG SDP SES SPC SPCBC SPD SSM SSQ T5K TN5 ~02 ~G- 29N 3O- 53G 6TJ 8WZ A6W AAEDT AAQXK AAXKI AAYXX ABFNM ABXDB ACNNM ADMUD AFFNX AFJKZ AGHFR ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 HME HVGLF HZ~ H~9 MVM R2- RIG SEW SHN SSZ VOH WUQ |
| ID | FETCH-LOGICAL-c1458-3e1760e4bd876a87e9796e481f901a906b59d0bbdf2e72a64b38631a30e317c43 |
| ISSN | 0168-583X |
| IngestDate | Thu Sep 26 16:33:50 EDT 2024 Fri Feb 23 02:47:17 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Diagnostic radionuclide Fusion-evaporation Medical-isotopes Heavy-ion-beams Isotope-production PET |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c1458-3e1760e4bd876a87e9796e481f901a906b59d0bbdf2e72a64b38631a30e317c43 |
| PageCount | 4 |
| ParticipantIDs | crossref_primary_10_1016_j_nimb_2021_02_008 elsevier_sciencedirect_doi_10_1016_j_nimb_2021_02_008 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-04-15 |
| PublicationDateYYYYMMDD | 2021-04-15 |
| PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationTitle | Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms |
| PublicationYear | 2021 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Beshara, Lundqvist, Sudin, Lubberink, Tolmachev, Valind, Antoni, Langstrom, Danielson (b0030) 1999; 104 Johnbeck, Knigge, Kjær (b0005) 2014; 10 Hermanne, Rebeles, Tárkányi, Takács (b0055) 2015; 356–357 Ziegler, Ziegler, Biersack (b0075) 2010; 268 Gavron (b0060) 1980; 21 Tarasov, Bazin (b0065) 2008; 266 S. Beshara, J. Sörensen, M. Lubberink, V. Tolmachev, B. Langstrom, G. Antoni, B. G Danielson, and H. Lundqvist, “Pharmacokinetics and red cell utilization of Fe-52/Fe-59-labelled iron polymaltose in anaemic patients using positron emission tomography,” British journal of Haematology, vol. 120, pp. 853-9, 04 2003. F. Akiha, T. Aburai, T. Nozaki, et al., “Yield of 52Fe for the reactions of 3He and on chromium,” Radiochimica Acta, vol. 18(2), pp. 108-111, 1972. Steyn, Mills, Nortier, Simpson, Meyer (b0050) 1990; 41 Conti, Eriksson (b0020) 2016; 3 Greene, Lebowitz, Richards, Hillman (b0040) 1970; 21 van Dongen, Visser, Lubde Hooge, De Vries, Perk (b0015) 2007; 12 Samuelson, Sjöberg (b0070) 1956; 14 Quigley, Colloby, O'Brien (b0010) 2011; 26 Wooten, Madrid, Schweitzer, Lawrence, Mebrahtu, Lewis, Lapi (b0025) 2013; 3 Greene (10.1016/j.nimb.2021.02.008_b0040) 1970; 21 Ziegler (10.1016/j.nimb.2021.02.008_b0075) 2010; 268 Johnbeck (10.1016/j.nimb.2021.02.008_b0005) 2014; 10 Wooten (10.1016/j.nimb.2021.02.008_b0025) 2013; 3 10.1016/j.nimb.2021.02.008_b0035 10.1016/j.nimb.2021.02.008_b0045 Tarasov (10.1016/j.nimb.2021.02.008_b0065) 2008; 266 Steyn (10.1016/j.nimb.2021.02.008_b0050) 1990; 41 Beshara (10.1016/j.nimb.2021.02.008_b0030) 1999; 104 Samuelson (10.1016/j.nimb.2021.02.008_b0070) 1956; 14 van Dongen (10.1016/j.nimb.2021.02.008_b0015) 2007; 12 Conti (10.1016/j.nimb.2021.02.008_b0020) 2016; 3 Gavron (10.1016/j.nimb.2021.02.008_b0060) 1980; 21 Quigley (10.1016/j.nimb.2021.02.008_b0010) 2011; 26 Hermanne (10.1016/j.nimb.2021.02.008_b0055) 2015; 356–357 |
| References_xml | – volume: 12 start-page: 1379 year: 2007 end-page: 1389 ident: b0015 article-title: Immuno-PET: a navigator in monoclonal antibody development and applications publication-title: Oncologist contributor: fullname: Perk – volume: 3 start-page: 593 year: 2013 end-page: 613 ident: b0025 article-title: Routine production of publication-title: Appl. Sci. contributor: fullname: Lapi – volume: 268 start-page: 1818 year: 2010 end-page: 1823 ident: b0075 article-title: SRIM - the stopping and range of ions in matter (2010) publication-title: Nucl. Instrum. Methods Phys. Res., Sect. B contributor: fullname: Biersack – volume: 10 start-page: 2259 year: 2014 end-page: 2277 ident: b0005 article-title: Pet tracers for somatostatin receptor imaging of neuroendocrine tumors: current status and review of the literature publication-title: Future Oncol. contributor: fullname: Kjær – volume: 356–357 start-page: 28 year: 2015 end-page: 41 ident: b0055 article-title: Alpha particle induced reactions on publication-title: Nucl. Instrum. Methods Phys. Res., Sect. B contributor: fullname: Takács – volume: 21 start-page: 230 year: 1980 end-page: 236 ident: b0060 article-title: Statistical model calculations in heavy ion reactions publication-title: Phys. Rev. C contributor: fullname: Gavron – volume: 104 start-page: 288 year: 1999 end-page: 295 ident: b0030 article-title: Kinetic analysis of 52Fe-labelled iron (III) hydroxide-sucrose complex following bolus administration using positron emission tomography publication-title: Br. J. Haematol. contributor: fullname: Danielson – volume: 21 start-page: 719 year: 1970 end-page: 723 ident: b0040 article-title: Production of 52Fe for medical use publication-title: Int. J. Appl. Radiation and Isotopes contributor: fullname: Hillman – volume: 3 start-page: May year: 2016 ident: b0020 article-title: Physics of pure and non-pure positron emitters for PET: a review and a discussion publication-title: EJNMMI Phys. contributor: fullname: Eriksson – volume: 26 start-page: 991 year: 2011 end-page: 999 ident: b0010 article-title: PET imaging of brain amyloid in dementia: a review publication-title: Int. J. Geriatric Psych. contributor: fullname: O'Brien – volume: 41 start-page: 315 year: 1990 end-page: 325 ident: b0050 article-title: “Production of 52Fe via proton-induced reactions on manganese and nickel”, International Journal of Radiation Applications and Instrumentation publication-title: Part A. Applied Radiation and Isotopes contributor: fullname: Meyer – volume: 266 year: 2008 ident: b0065 article-title: LISE++: Radioactive beam production with in-flight separators publication-title: Nucl. Instrum. Methods Phys. Res., Sect. B contributor: fullname: Bazin – volume: 14 start-page: 121 year: 1956 end-page: 125 ident: b0070 article-title: Separation of calcium and aluminum from iron by an ion exchange method publication-title: Anal. Chim. Acta contributor: fullname: Sjöberg – volume: 26 start-page: 991 issue: 10 year: 2011 ident: 10.1016/j.nimb.2021.02.008_b0010 article-title: PET imaging of brain amyloid in dementia: a review publication-title: Int. J. Geriatric Psych. doi: 10.1002/gps.2640 contributor: fullname: Quigley – ident: 10.1016/j.nimb.2021.02.008_b0035 doi: 10.1046/j.1365-2141.2003.03590.x – volume: 356–357 start-page: 28 year: 2015 ident: 10.1016/j.nimb.2021.02.008_b0055 article-title: Alpha particle induced reactions on natCr up to 39MeV: Experimental cross-sections, comparison with theoretical calculations and thick target yields for medically relevant 52gFe production publication-title: Nucl. Instrum. Methods Phys. Res., Sect. B doi: 10.1016/j.nimb.2015.04.025 contributor: fullname: Hermanne – volume: 14 start-page: 121 year: 1956 ident: 10.1016/j.nimb.2021.02.008_b0070 article-title: Separation of calcium and aluminum from iron by an ion exchange method publication-title: Anal. Chim. Acta doi: 10.1016/0003-2670(56)80137-2 contributor: fullname: Samuelson – volume: 104 start-page: 288 year: 1999 ident: 10.1016/j.nimb.2021.02.008_b0030 article-title: Kinetic analysis of 52Fe-labelled iron (III) hydroxide-sucrose complex following bolus administration using positron emission tomography publication-title: Br. J. Haematol. doi: 10.1046/j.1365-2141.1999.01170.x contributor: fullname: Beshara – volume: 21 start-page: 719 issue: 12 year: 1970 ident: 10.1016/j.nimb.2021.02.008_b0040 article-title: Production of 52Fe for medical use publication-title: Int. J. Appl. Radiation and Isotopes doi: 10.1016/0020-708X(70)90081-5 contributor: fullname: Greene – volume: 21 start-page: 230 year: 1980 ident: 10.1016/j.nimb.2021.02.008_b0060 article-title: Statistical model calculations in heavy ion reactions publication-title: Phys. Rev. C doi: 10.1103/PhysRevC.21.230 contributor: fullname: Gavron – volume: 3 start-page: May year: 2016 ident: 10.1016/j.nimb.2021.02.008_b0020 article-title: Physics of pure and non-pure positron emitters for PET: a review and a discussion publication-title: EJNMMI Phys. doi: 10.1186/s40658-016-0144-5 contributor: fullname: Conti – ident: 10.1016/j.nimb.2021.02.008_b0045 doi: 10.1524/ract.1972.18.2.108 – volume: 41 start-page: 315 issue: 3 year: 1990 ident: 10.1016/j.nimb.2021.02.008_b0050 article-title: “Production of 52Fe via proton-induced reactions on manganese and nickel”, International Journal of Radiation Applications and Instrumentation publication-title: Part A. Applied Radiation and Isotopes doi: 10.1016/0883-2889(90)90197-O contributor: fullname: Steyn – volume: 266 year: 2008 ident: 10.1016/j.nimb.2021.02.008_b0065 article-title: LISE++: Radioactive beam production with in-flight separators publication-title: Nucl. Instrum. Methods Phys. Res., Sect. B doi: 10.1016/j.nimb.2008.05.110 contributor: fullname: Tarasov – volume: 3 start-page: 593 issue: 3 year: 2013 ident: 10.1016/j.nimb.2021.02.008_b0025 article-title: Routine production of 89Zr using an automated module publication-title: Appl. Sci. doi: 10.3390/app3030593 contributor: fullname: Wooten – volume: 268 start-page: 1818 issue: 11 year: 2010 ident: 10.1016/j.nimb.2021.02.008_b0075 article-title: SRIM - the stopping and range of ions in matter (2010) publication-title: Nucl. Instrum. Methods Phys. Res., Sect. B doi: 10.1016/j.nimb.2010.02.091 contributor: fullname: Ziegler – volume: 12 start-page: 1379 issue: 12 year: 2007 ident: 10.1016/j.nimb.2021.02.008_b0015 article-title: Immuno-PET: a navigator in monoclonal antibody development and applications publication-title: Oncologist doi: 10.1634/theoncologist.12-12-1379 contributor: fullname: van Dongen – volume: 10 start-page: 2259 issue: 14 year: 2014 ident: 10.1016/j.nimb.2021.02.008_b0005 article-title: Pet tracers for somatostatin receptor imaging of neuroendocrine tumors: current status and review of the literature publication-title: Future Oncol. doi: 10.2217/fon.14.139 contributor: fullname: Johnbeck |
| SSID | ssj0000535 |
| Score | 2.3652785 |
| Snippet | A promising method for the production and extraction of 52Fe utilizing near-symmetric, heavy-ion fusion-evaporation reactions is presented. A 28Si beam was... |
| SourceID | crossref elsevier |
| SourceType | Aggregation Database Publisher |
| StartPage | 15 |
| SubjectTerms | Diagnostic radionuclide Fusion-evaporation Heavy-ion-beams Isotope-production Medical-isotopes PET |
| Title | Production of 52Fe from symmetric complete fusion-evaporation reactions |
| URI | https://dx.doi.org/10.1016/j.nimb.2021.02.008 |
| Volume | 493 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3di9QwEA_rHYIv4ieeX_TBtyVLm6Rp83ieq-chcrgr7FtJ2hTcs93j7lbwv3em07SLK6KCL6WkNBtmfjv5dTIfjL1yqbZ5lRouhZVclaXhVviKlyo11ngrK4d-yNNF9nGVv5mr-WQSuq2OY_9V0zAGusbM2b_Q9jApDMA96ByuoHW4_pHez6mEa88DU1gcpZBcf28a7J5VUhQ5cOVpvUVXGfff7GUAAlDIcnThrUNubonNJTBu_QZrLWDkDCKGuk9TIHqnbjyCCDWUF54W8bpDkLdNV5niqp-e_L_AlkkkVDL2ZtMMDL_LQGvRDnf-WTwv-DTbcX5f9Y5b22z91-nZ8Ais3MWQ0NaFBS2HZx822GWDZjyZYa3qbbvr9RAJHuBQ3ie54vbSccg7SmlkK9rcyKLnmeAmpT50weQrI3eMdj8vbf-0G-xtLOTjWM_aL42b4YKo0ms-bqNDcOMCl4GrEEl3EAoE4VCAGQQrfHj8fr46G5lCSg1gw7L7pC6KP_z5l35NnHbI0PIeu9t_xUTHBL_7bOLbB-z2OYHgIXs3gjDa1BGCMEIQRgMIowDCaB-E0QDCR-zz2_ny5JT3HTt4mag059InmY69chVssjbPvMmM9ipPaqCd1sTapaaKnatq4TNhtXIy1zKxMvbAY0slH7ODdtP6JyySTtdZnWAlEatQQtrb2MH3vrZaujI7YtMgjuKSCrMUIWJxXaDwChReEYsChHfE0iCxoqeWRBkLUPBv3nv6j-89Y3dG1D5nB_Dv9C_Yretq-7IHwQ_Xm515 |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Production+of+52Fe+from+symmetric+complete+fusion-evaporation+reactions&rft.jtitle=Nuclear+instruments+%26+methods+in+physics+research.+Section+B%2C+Beam+interactions+with+materials+and+atoms&rft.au=McGuinness%2C+Sean+R.&rft.au=Ferran%2C+Samuel+J.&rft.au=Wilkinson%2C+John+T.&rft.au=Loveless%2C+C.+Shaun&rft.date=2021-04-15&rft.pub=Elsevier+B.V&rft.issn=0168-583X&rft.eissn=1872-9584&rft.volume=493&rft.spage=15&rft.epage=18&rft_id=info:doi/10.1016%2Fj.nimb.2021.02.008&rft.externalDocID=S0168583X21000732 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-583X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-583X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-583X&client=summon |