Nicotinic acetylcholine receptors: specific antibodies and functions in humoral immunity

Nicotinic acetylcholine receptors: specific antibodies and functions in humoral immunity

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels initially discovered in muscles and neurons and further found in many non-excitable cells. The present review summarizes the results of studies performed in the Department of Molecular Immunology during the last decade and conc...

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Bibliographic Details
Published in:Ukrainian biochemical journal Vol. 85; no. 6; pp. 134 - 143
Main Authors: M. V. Skok, L. M. Koval, O. Yu. Lykhmus, O. M. Kalashnyk, G. L. Gergalova, S. V. Komisarenko
Format: Journal Article
Language:English
Published: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 27-12-2013
Subjects:
Alzheimer’s disease
antibodies
B lymphocytes
mitochondria
nicotinic acetylcholine receptors
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Summary:Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels initially discovered in muscles and neurons and further found in many non-excitable cells. The present review summarizes the results of studies performed in the Department of Molecular Immunology during the last decade and concerning the structure and functions of nAChRs in B lymphocytes and in mitochondria, as well as the role of nAChR-specific antibodies in the develop­ment of neurodegenerative disorders like Alzheimer disease.
ISSN:2409-4943
2413-5003
DOI:10.15407/ubj85.06.134