An Aptamer-based Electrochemical-Sensing Implant for Continuous Therapeutic- Drug Monitoring in vivo

• Published in: 2019 Symposium on VLSI Circuits pp. C312 - C313
• Main Authors: Chien, Jun-Chau, Mage, Peter L., Soh, H. Tom, Arbabian, Amin
• Format: Conference Proceeding
• Language: English
• Published: JSAP 01-06-2019
• Subjects: Very large scale integration
• ISSN: 2158-5636
• DOI: 10.23919/VLSIC.2019.8777991

This work presents the first fully wireless implant system capable of continuous monitoring of therapeutic drugs in vivo. Electrochemical readout using square-wave voltammetry (SWV) is employed to measure the changes in the drug concentration using redox-labeled structure-switching aptamers. Ultrasound (US) powering and data transmission are employed in the implant for miniaturization, large tissue depth, and high available power. We demonstrate continuous and real-time detection in the human whole blood. Implemented in 65-nm CMOS, the entire implant system operates at 6.64 mW, and measures 140mm 3 and 0.24g.