Soluble adhesion molecules in serum and peritoneal fluid are associated with pelvic pain in endometriosis
Elevated levels of serum and peritoneal soluble adhesion molecules sE‐selectin and sICAM‐1 are associated with pelvic pain in infertile women with endometriosis, suggesting their potential involvement in disease development and as possible biomarkers.
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| Published in: | International journal of gynecology and obstetrics |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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08-11-2024
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| Abstract | Elevated levels of serum and peritoneal soluble adhesion molecules sE‐selectin and sICAM‐1 are associated with pelvic pain in infertile women with endometriosis, suggesting their potential involvement in disease development and as possible biomarkers. |
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| AbstractList | Elevated levels of serum and peritoneal soluble adhesion molecules sE‐selectin and sICAM‐1 are associated with pelvic pain in infertile women with endometriosis, suggesting their potential involvement in disease development and as possible biomarkers. To investigate the association between soluble adhesion molecules (sE-cadherin, sE-selectin, sICAM-1, sVCAM-1) in serum and peritoneal fluid and pelvic pain in infertile women with endometriosis.OBJECTIVETo investigate the association between soluble adhesion molecules (sE-cadherin, sE-selectin, sICAM-1, sVCAM-1) in serum and peritoneal fluid and pelvic pain in infertile women with endometriosis.This observational study included 86 infertile women undergoing diagnostic laparoscopy, 43 of whom were diagnosed with endometriosis. Pain intensity was evaluated using the visual analog scale (VAS). Levels of soluble adhesion molecules in serum and peritoneal fluid were quantified using ELISA. Statistical analysis included the Mann-Whitney U test for group comparisons, Spearman's rank correlation for associations with VAS scores, and receiver operating characteristic (ROC) curve analysis for diagnostic performance.METHODSThis observational study included 86 infertile women undergoing diagnostic laparoscopy, 43 of whom were diagnosed with endometriosis. Pain intensity was evaluated using the visual analog scale (VAS). Levels of soluble adhesion molecules in serum and peritoneal fluid were quantified using ELISA. Statistical analysis included the Mann-Whitney U test for group comparisons, Spearman's rank correlation for associations with VAS scores, and receiver operating characteristic (ROC) curve analysis for diagnostic performance.Serum sE-selectin levels were significantly higher in women with pelvic pain (P = 0.022) and correlated with VAS scores (r = 0.271, P = 0.012). Peritoneal sE-selectin and sICAM-1 levels were elevated in women with pelvic pain (P = 0.044 and P = 0.029, respectively) and showed positive correlations with VAS scores (r = 0.246, P = 0.022 and r = 0.310, P = 0.004, respectively). Comparing endometriosis and control groups, peritoneal sE-selectin and sICAM-1 levels were significantly higher in endometriosis cases with pelvic pain (P = 0.003 and P < 0.001, respectively). ROC analysis revealed the potential diagnostic value of serum sE-selectin (AUC = 0.698, P = 0.002), serum sICAM-1 (AUC = 0.721, P < 0.001), and serum sVCAM-1 (AUC = 0.750, P < 0.001) in distinguishing endometriosis from non-endometriosis cases.RESULTSSerum sE-selectin levels were significantly higher in women with pelvic pain (P = 0.022) and correlated with VAS scores (r = 0.271, P = 0.012). Peritoneal sE-selectin and sICAM-1 levels were elevated in women with pelvic pain (P = 0.044 and P = 0.029, respectively) and showed positive correlations with VAS scores (r = 0.246, P = 0.022 and r = 0.310, P = 0.004, respectively). Comparing endometriosis and control groups, peritoneal sE-selectin and sICAM-1 levels were significantly higher in endometriosis cases with pelvic pain (P = 0.003 and P < 0.001, respectively). ROC analysis revealed the potential diagnostic value of serum sE-selectin (AUC = 0.698, P = 0.002), serum sICAM-1 (AUC = 0.721, P < 0.001), and serum sVCAM-1 (AUC = 0.750, P < 0.001) in distinguishing endometriosis from non-endometriosis cases.Elevated levels of sE-selectin and sICAM-1 in serum and peritoneal fluid are associated with pelvic pain in women with endometriosis, suggesting their role in pain pathogenesis and potential as biomarkers for pain severity and disease diagnosis. Further research is warranted to explore the underlying mechanisms and validate these findings in larger cohorts.CONCLUSIONElevated levels of sE-selectin and sICAM-1 in serum and peritoneal fluid are associated with pelvic pain in women with endometriosis, suggesting their role in pain pathogenesis and potential as biomarkers for pain severity and disease diagnosis. Further research is warranted to explore the underlying mechanisms and validate these findings in larger cohorts. |
| Author | Alditia, Fidyah Nanda Dwiningsih, Sri Ratna Tunjungseto, Arif Mufid, Alfin Firasy Rahmawati, Nanda Yuli Ahsan, Fadhil Santoso, Budi Sa'adi, Ashon Widyanugraha, M. Y. Ardianta |
| Author_xml | – sequence: 1 givenname: Fadhil orcidid: 0000-0002-9302-3804 surname: Ahsan fullname: Ahsan, Fadhil organization: Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Airlangga Surabaya Indonesia – sequence: 2 givenname: Budi surname: Santoso fullname: Santoso, Budi organization: Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Airlangga Surabaya Indonesia – sequence: 3 givenname: Nanda Yuli surname: Rahmawati fullname: Rahmawati, Nanda Yuli organization: Doctoral Program of Medical Science, Faculty of Medicine Universitas Airlangga Surabaya Indonesia – sequence: 4 givenname: Fidyah Nanda surname: Alditia fullname: Alditia, Fidyah Nanda organization: Department of Internal Medicine Elbe‐Elster Klinikum Finsterwalde Germany – sequence: 5 givenname: Alfin Firasy surname: Mufid fullname: Mufid, Alfin Firasy organization: Doctoral Program of Medical Science, Faculty of Medicine Universitas Airlangga Surabaya Indonesia – sequence: 6 givenname: Ashon surname: Sa'adi fullname: Sa'adi, Ashon organization: Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Airlangga Surabaya Indonesia – sequence: 7 givenname: Sri Ratna surname: Dwiningsih fullname: Dwiningsih, Sri Ratna organization: Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Airlangga Surabaya Indonesia – sequence: 8 givenname: Arif surname: Tunjungseto fullname: Tunjungseto, Arif organization: Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Airlangga Surabaya Indonesia, Doctoral Program of Medical Science, Faculty of Medicine Universitas Airlangga Surabaya Indonesia – sequence: 9 givenname: M. Y. Ardianta surname: Widyanugraha fullname: Widyanugraha, M. Y. Ardianta organization: Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Airlangga Surabaya Indonesia, Doctoral Program of Medical Science, Faculty of Medicine Universitas Airlangga Surabaya Indonesia |
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| Snippet | Elevated levels of serum and peritoneal soluble adhesion molecules sE‐selectin and sICAM‐1 are associated with pelvic pain in infertile women with... To investigate the association between soluble adhesion molecules (sE-cadherin, sE-selectin, sICAM-1, sVCAM-1) in serum and peritoneal fluid and pelvic pain in... |
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