Efficient Elimination of Acute Myeloid Leukemia Cells through Inhibition of KDM4A in Combination with PARP Inhibition

Epigenetic therapies are emerging as a promising therapeutic strategy for acute myeloid leukemia (AML), exemplified by advances in the development of inhibitors targeting DNMT3A, DOT1L and LSD1. We identified an essential role for the H3K9me3 histone demethylase, KDM4A, in maintaining AML cell survi...

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Bibliographic Details

Published in:	Blood Vol. 134; no. Supplement_1; p. 3756
Main Authors:	Monaghan, Laura, Massett, Matthew Edward, Bunschoten, Roderick P, Pirvan, Petrisor Alin, Hoose, Alex, Park, Taeju, Bittencourt-Silvestre, Joana, Liskamp, Robert M J, Jørgensen, Heather G, Huang, Xu
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 13-11-2019
Online Access:	Get full text
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