Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes

Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes

Lys-Gluin vitro stimulated interleukin-2 gene expression in mouse spleen lymphocytes. This effect depended on peptide concentration, and duration of treatment. It is hypothesized that this peptide is the shortest regulatory fragment promoting the transport of trans-acting factors into the nucleus. I...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 130; no. 3; pp. 898 - 899
Main Authors: Khavinson, V. Kh, Morozov, V. G., Malinin, V. V., Kazakova, T. B., Korneva, E. A.
Format: Journal Article
Language:English
Published: New York Springer Nature B.V 01-09-2000
Subjects:
Cell activation
Gene expression
Lymphocytes
Peptides
Proteins
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Summary:Lys-Gluin vitro stimulated interleukin-2 gene expression in mouse spleen lymphocytes. This effect depended on peptide concentration, and duration of treatment. It is hypothesized that this peptide is the shortest regulatory fragment promoting the transport of trans-acting factors into the nucleus. It can not be excluded that Lys-Glu is a structural component of transacting factor active centers, which are necessary for the activation of interleukin-2 gene transcription in lymphocytes.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/BF02682264