Cover Feature: New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer (Chem. Eur. J. 66/2020)

Cover Feature: New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer (Chem. Eur. J. 66/2020)

Three birds with one stone: New therapies are needed to facilitate synergistic combinations that span distinct antitumor mechanisms. A small library of structurally relevant C,N‐cyclometalated ruthenium(II) complexes was synthesized and their pharmacologic efficacy was investigated. The cover art sh...

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Bibliographic Details
Published in:Chemistry : a European journal Vol. 26; no. 66; p. 15050
Main Authors: Wang, Yuchen, Jin, Jiahui, Shu, Liwei, Li, Tongyu, Lu, Siming, Subarkhan, Mohamed Kasim Mohamed, Chen, Chao, Wang, Hangxiang
Format: Journal Article
Language:English
Published: 26-11-2020
Subjects:
antiangiogenesis
antimetastasis
cancer chemotherapy
cytotoxicity
ruthenium(II) complexes
Online Access:Get full text
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Summary:Three birds with one stone: New therapies are needed to facilitate synergistic combinations that span distinct antitumor mechanisms. A small library of structurally relevant C,N‐cyclometalated ruthenium(II) complexes was synthesized and their pharmacologic efficacy was investigated. The cover art shows the structure of the complex Ru8, which was demonstrated to have three antitumor functions, including potent cytotoxicity, antimetastasis and antivascular activity. The complex deserves further investigation as a promising drug candidate to combat metastatic cancer. More information can be found in the Full Paper by C. Chen, H. Wang, et al. on page 15170.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202004199