Induced-Fit Binding of a Polyproline Helix by a β-Hairpin Peptide

Induced-Fit Binding of a Polyproline Helix by a β-Hairpin Peptide

Ein Minimalmimetikum einer Proteindomäne, die über eine aromatische Tasche an Typ‐II‐Polyprolinhelices bindet, wurde untersucht. Dieses Bindungsmotiv wird auch in Proteindomänen mit Bezug zu HIV‐Infektion und Krebs angetroffen. Die Studie gibt Einblicke in die Struktur‐Bindungs‐Beziehung und liefert...

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Published in:Angewandte Chemie Vol. 123; no. 51; pp. 12409 - 12412
Main Authors: Wilger, Dale J., Park, Jessica H., Hughes, Robert M., Cuellar, Matthew E., Waters, Marcey L.
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 16-12-2011
WILEY‐VCH Verlag
Subjects:
Peptidstrukturen
Prolyl-π-Wechselwirkung
Protein-Protein-Wechselwirkungen
Proteinmimetika
β-Haarnadelstrukturen
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Abstract Ein Minimalmimetikum einer Proteindomäne, die über eine aromatische Tasche an Typ‐II‐Polyprolinhelices bindet, wurde untersucht. Dieses Bindungsmotiv wird auch in Proteindomänen mit Bezug zu HIV‐Infektion und Krebs angetroffen. Die Studie gibt Einblicke in die Struktur‐Bindungs‐Beziehung und liefert quantitative Daten zur Stärke von Prolyl‐π‐Wechselwirkungen, die wichtig für den Entwurf von Hemmstoffen sind.
AbstractList Ein Minimalmimetikum einer Proteindomäne, die über eine aromatische Tasche an Typ‐II‐Polyprolinhelices bindet, wurde untersucht. Dieses Bindungsmotiv wird auch in Proteindomänen mit Bezug zu HIV‐Infektion und Krebs angetroffen. Die Studie gibt Einblicke in die Struktur‐Bindungs‐Beziehung und liefert quantitative Daten zur Stärke von Prolyl‐π‐Wechselwirkungen, die wichtig für den Entwurf von Hemmstoffen sind.
Author Park, Jessica H.
Cuellar, Matthew E.
Waters, Marcey L.
Hughes, Robert M.
Wilger, Dale J.
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  givenname: Marcey L.
  surname: Waters
  fullname: Waters, Marcey L.
  email: mlwaters@unc.edu
  organization: Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
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Snippet Ein Minimalmimetikum einer Proteindomäne, die über eine aromatische Tasche an Typ‐II‐Polyprolinhelices bindet, wurde untersucht. Dieses Bindungsmotiv wird auch...
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SubjectTerms Peptidstrukturen
Prolyl-π-Wechselwirkung
Protein-Protein-Wechselwirkungen
Proteinmimetika
β-Haarnadelstrukturen
Title Induced-Fit Binding of a Polyproline Helix by a β-Hairpin Peptide
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