TSH au cordon élevées au Maroc : hypothyroïdie iatrogène ?
Une courte étude prospective de la fonction thyroïdienne du nouveau-né à terme (n = 90) a été réalisée dans une maternité de Marrakech (Maroc), en préliminaire à la validation de l’efficacité du programme national d’iodisation du sel. La TSH était élevée (> 5 mU/l) chez 89 % des nouveau-nés. L’io...
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Published in: | Annales d'endocrinologie Vol. 67; no. 1; pp. 39 - 41 |
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Abstract | Une courte étude prospective de la fonction thyroïdienne du nouveau-né à terme (n = 90) a été réalisée dans une maternité de Marrakech (Maroc), en préliminaire à la validation de l’efficacité du programme national d’iodisation du sel. La TSH était élevée (> 5 mU/l) chez 89 % des nouveau-nés. L’iodurie mesurée chez 35 des mères était normale (100-200 μg/l) ou élevée (> 200 μg/l) (n = 27). La concentration de l’iode dans le lait maternel de 315 femmes de la même région était inférieure à la valeur normale (41 μg/l) chez 60 % d’entre elles.
L’iodurie élevée observée à l’accouchement peut être associée à l’utilisation habituelle des désinfectants iodés, mais la carence en iode semble rester fréquente chez cette population et justifie une enquête à grande échelle, d’autant que le risque lié à une hypothyroïdie transitoire du nouveau-né n’est pas connu.
A short prospective study was conducted to assess thyroid status in healthy full term newborns (n=90) of a large maternity of Marrakech (Morocco), as part of the validation of a national salt iodisation program. High TSH (>5mU/l) was detected in 89% of infants tested; urinary iodine excretion was measured in 35 of the mothers, and was found to be normal (100-200g/l) or high (>200g/l)(n=27) in all of them. Milk iodine concentration was measured in 315 lactating women from the same area. Low values (<41g/l) were found in 60% of them.
The common use of iodinated disinfectants during delivery could be responsible for the high urine iodine values of mothers; however iodine deficiency seems to remain a widespread problem in this population and justifies a large scale survey of iodine status. |
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AbstractList | Une courte étude prospective de la fonction thyroïdienne du nouveau-né à terme (n = 90) a été réalisée dans une maternité de Marrakech (Maroc), en préliminaire à la validation de l’efficacité du programme national d’iodisation du sel. La TSH était élevée (> 5 mU/l) chez 89 % des nouveau-nés. L’iodurie mesurée chez 35 des mères était normale (100-200 μg/l) ou élevée (> 200 μg/l) (n = 27). La concentration de l’iode dans le lait maternel de 315 femmes de la même région était inférieure à la valeur normale (41 μg/l) chez 60 % d’entre elles.
L’iodurie élevée observée à l’accouchement peut être associée à l’utilisation habituelle des désinfectants iodés, mais la carence en iode semble rester fréquente chez cette population et justifie une enquête à grande échelle, d’autant que le risque lié à une hypothyroïdie transitoire du nouveau-né n’est pas connu.
A short prospective study was conducted to assess thyroid status in healthy full term newborns (n=90) of a large maternity of Marrakech (Morocco), as part of the validation of a national salt iodisation program. High TSH (>5mU/l) was detected in 89% of infants tested; urinary iodine excretion was measured in 35 of the mothers, and was found to be normal (100-200g/l) or high (>200g/l)(n=27) in all of them. Milk iodine concentration was measured in 315 lactating women from the same area. Low values (<41g/l) were found in 60% of them.
The common use of iodinated disinfectants during delivery could be responsible for the high urine iodine values of mothers; however iodine deficiency seems to remain a widespread problem in this population and justifies a large scale survey of iodine status. |
Author | Sedki, A. Lekouch, N. Bouglé, D. Zaida, F. Laroche, D. |
Author_xml | – sequence: 1 givenname: F. surname: Zaida fullname: Zaida, F. organization: Laboratoire d’écotoxicologie, Faculté des sciences Semlalia, Université Cadi Ayyad, Marrakech, Maroc – sequence: 2 givenname: A. surname: Sedki fullname: Sedki, A. organization: Laboratoire d’écotoxicologie, Faculté des sciences Semlalia, Université Cadi Ayyad, Marrakech, Maroc – sequence: 3 givenname: D. surname: Laroche fullname: Laroche, D. organization: Laboratoire de Radio-immunologie, CHU de Caen, 14033 Caen Cedex, France – sequence: 4 givenname: N. surname: Lekouch fullname: Lekouch, N. organization: Laboratoire d’écotoxicologie, Faculté des sciences Semlalia, Université Cadi Ayyad, Marrakech, Maroc – sequence: 5 givenname: D. surname: Bouglé fullname: Bouglé, D. email: bougle-d@chu-caen.fr organization: Service de Pédiatrie, CHU de Caen, France |
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Cites_doi | 10.1007/BF01954494 10.1111/j.1753-4887.2001.tb05512.x 10.1210/jcem-59-1-90 10.1385/BTER:79:2:121 10.1089/thy.2000.10.991 10.1007/BF03345821 10.1093/clinchem/34.3.474 |
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DocumentTitleAlternate | High cord blood TSH in Morocco: iatrogenic hypothyroidism? |
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Keywords | Morocco iode TSH nouveau-né Maroc newborn Iodine Sang Homme Hormone adénohypophysaire Endocrinopathie Hypothyroïdie Thyroïde pathologie Nouveau né |
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References_xml | – volume: 153 start-page: 756 year: 1994 end-page: 758 ident: bib7 article-title: Povidone-iodine in umbilical cord care interferes with neonatal screening for hypothyroidism publication-title: Eur J Pediatr contributor: fullname: Wu – volume: 10 start-page: 991 year: 2000 end-page: 999 ident: bib10 article-title: The auditory threshold in a school-age population is related to iodine intake and thyroid function publication-title: Thyroid contributor: fullname: Munoz – volume: 187 start-page: 6 year: 1983 end-page: 10 ident: bib5 article-title: Radio- in vitro studies of the thyroid status of mature newborn infants immediately post partum publication-title: Z Geburtshilfe Perinatol contributor: fullname: Grebe – volume: 59 start-page: 269 year: 2001 end-page: 278 ident: bib9 article-title: Iodine in human milk: perspectives for infant health publication-title: Nutr Rev contributor: fullname: Delange – start-page: 173 year: 1989 end-page: 182 ident: bib3 article-title: Iodine nutrition and congenital hypothyroidism publication-title: Research in congenital hypothyroidism contributor: fullname: Delange – volume: 34 start-page: 474 year: 1988 end-page: 481 ident: bib6 article-title: Trace elements in human clinical specimens: evaluation of literature data to identify reference values publication-title: Clin Chem contributor: fullname: Woittiez – volume: 79 start-page: 121 year: 2001 end-page: 130 ident: bib4 article-title: Endemic goiter, thiocyanate overload, and selenium status in school-age children publication-title: Biol Tr Elem Res contributor: fullname: Kamel – volume: 1 start-page: 795 year: 1994 end-page: 800 ident: bib11 article-title: Brief antiseptic application of iodine in neonatal intensive care units: effects on thyroid function publication-title: Arch Pediatr contributor: fullname: Aufrant – volume: 59 start-page: 90 year: 1984 end-page: 95 ident: bib8 article-title: Transient impairment of thyroid function in newborn from an area of endemic goiter publication-title: J Clin Endocrinol Metab contributor: fullname: Vigenri – volume: 16 start-page: 9 year: 1993 end-page: 14 ident: bib1 article-title: Endemic goiter in Morocco (Skoura- Toundoute area in the high Atlas) publication-title: J Endocrinol Invest contributor: fullname: Ardissone – volume: 153 start-page: 756 year: 1994 ident: 10.1016/S0003-4266(06)72538-0_bib7 article-title: Povidone-iodine in umbilical cord care interferes with neonatal screening for hypothyroidism publication-title: Eur J Pediatr doi: 10.1007/BF01954494 contributor: fullname: Lin – volume: 59 start-page: 269 year: 2001 ident: 10.1016/S0003-4266(06)72538-0_bib9 article-title: Iodine in human milk: perspectives for infant health publication-title: Nutr Rev doi: 10.1111/j.1753-4887.2001.tb05512.x contributor: fullname: Semba – volume: 59 start-page: 90 year: 1984 ident: 10.1016/S0003-4266(06)72538-0_bib8 article-title: Transient impairment of thyroid function in newborn from an area of endemic goiter publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-59-1-90 contributor: fullname: Sava – ident: 10.1016/S0003-4266(06)72538-0_bib2 – volume: 79 start-page: 121 year: 2001 ident: 10.1016/S0003-4266(06)72538-0_bib4 article-title: Endemic goiter, thiocyanate overload, and selenium status in school-age children publication-title: Biol Tr Elem Res doi: 10.1385/BTER:79:2:121 contributor: fullname: Erdogan – volume: 187 start-page: 6 year: 1983 ident: 10.1016/S0003-4266(06)72538-0_bib5 article-title: Radio- in vitro studies of the thyroid status of mature newborn infants immediately post partum publication-title: Z Geburtshilfe Perinatol contributor: fullname: Gent – volume: 10 start-page: 991 year: 2000 ident: 10.1016/S0003-4266(06)72538-0_bib10 article-title: The auditory threshold in a school-age population is related to iodine intake and thyroid function publication-title: Thyroid doi: 10.1089/thy.2000.10.991 contributor: fullname: Soriguer – volume: 16 start-page: 9 year: 1993 ident: 10.1016/S0003-4266(06)72538-0_bib1 article-title: Endemic goiter in Morocco (Skoura- Toundoute area in the high Atlas) publication-title: J Endocrinol Invest doi: 10.1007/BF03345821 contributor: fullname: Aquaron – volume: 34 start-page: 474 year: 1988 ident: 10.1016/S0003-4266(06)72538-0_bib6 article-title: Trace elements in human clinical specimens: evaluation of literature data to identify reference values publication-title: Clin Chem doi: 10.1093/clinchem/34.3.474 contributor: fullname: Iyengar – volume: 1 start-page: 795 year: 1994 ident: 10.1016/S0003-4266(06)72538-0_bib11 article-title: Brief antiseptic application of iodine in neonatal intensive care units: effects on thyroid function publication-title: Arch Pediatr contributor: fullname: Vilain – start-page: 173 year: 1989 ident: 10.1016/S0003-4266(06)72538-0_bib3 article-title: Iodine nutrition and congenital hypothyroidism contributor: fullname: Delange – ident: 10.1016/S0003-4266(06)72538-0_bib12 |
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SubjectTerms | Endocrinopathies iode Iodine Maroc Morocco newborn nouveau-né Pathologie non tumorale. Résistance tissu cible. Tumeurs bénignes Sciences biologiques et medicales Sciences biologiques fondamentales et appliquees. Psychologie Sciences medicales Thyroïde. Axe thyroïdien (pathologie) TSH Vertebres: endocrinologie |
Title | TSH au cordon élevées au Maroc : hypothyroïdie iatrogène ? |
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