TSH au cordon élevées au Maroc : hypothyroïdie iatrogène ?

Une courte étude prospective de la fonction thyroïdienne du nouveau-né à terme (n = 90) a été réalisée dans une maternité de Marrakech (Maroc), en préliminaire à la validation de l’efficacité du programme national d’iodisation du sel. La TSH était élevée (> 5 mU/l) chez 89 % des nouveau-nés. L’io...

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Published in:Annales d'endocrinologie Vol. 67; no. 1; pp. 39 - 41
Main Authors: Zaida, F., Sedki, A., Laroche, D., Lekouch, N., Bouglé, D.
Format: Journal Article
Language:French
Published: Paris Elsevier Masson SAS 01-03-2006
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Abstract Une courte étude prospective de la fonction thyroïdienne du nouveau-né à terme (n = 90) a été réalisée dans une maternité de Marrakech (Maroc), en préliminaire à la validation de l’efficacité du programme national d’iodisation du sel. La TSH était élevée (> 5 mU/l) chez 89 % des nouveau-nés. L’iodurie mesurée chez 35 des mères était normale (100-200 μg/l) ou élevée (> 200 μg/l) (n = 27). La concentration de l’iode dans le lait maternel de 315 femmes de la même région était inférieure à la valeur normale (41 μg/l) chez 60 % d’entre elles. L’iodurie élevée observée à l’accouchement peut être associée à l’utilisation habituelle des désinfectants iodés, mais la carence en iode semble rester fréquente chez cette population et justifie une enquête à grande échelle, d’autant que le risque lié à une hypothyroïdie transitoire du nouveau-né n’est pas connu. A short prospective study was conducted to assess thyroid status in healthy full term newborns (n=90) of a large maternity of Marrakech (Morocco), as part of the validation of a national salt iodisation program. High TSH (>5mU/l) was detected in 89% of infants tested; urinary iodine excretion was measured in 35 of the mothers, and was found to be normal (100-200g/l) or high (>200g/l)(n=27) in all of them. Milk iodine concentration was measured in 315 lactating women from the same area. Low values (<41g/l) were found in 60% of them. The common use of iodinated disinfectants during delivery could be responsible for the high urine iodine values of mothers; however iodine deficiency seems to remain a widespread problem in this population and justifies a large scale survey of iodine status.
AbstractList Une courte étude prospective de la fonction thyroïdienne du nouveau-né à terme (n = 90) a été réalisée dans une maternité de Marrakech (Maroc), en préliminaire à la validation de l’efficacité du programme national d’iodisation du sel. La TSH était élevée (> 5 mU/l) chez 89 % des nouveau-nés. L’iodurie mesurée chez 35 des mères était normale (100-200 μg/l) ou élevée (> 200 μg/l) (n = 27). La concentration de l’iode dans le lait maternel de 315 femmes de la même région était inférieure à la valeur normale (41 μg/l) chez 60 % d’entre elles. L’iodurie élevée observée à l’accouchement peut être associée à l’utilisation habituelle des désinfectants iodés, mais la carence en iode semble rester fréquente chez cette population et justifie une enquête à grande échelle, d’autant que le risque lié à une hypothyroïdie transitoire du nouveau-né n’est pas connu. A short prospective study was conducted to assess thyroid status in healthy full term newborns (n=90) of a large maternity of Marrakech (Morocco), as part of the validation of a national salt iodisation program. High TSH (>5mU/l) was detected in 89% of infants tested; urinary iodine excretion was measured in 35 of the mothers, and was found to be normal (100-200g/l) or high (>200g/l)(n=27) in all of them. Milk iodine concentration was measured in 315 lactating women from the same area. Low values (<41g/l) were found in 60% of them. The common use of iodinated disinfectants during delivery could be responsible for the high urine iodine values of mothers; however iodine deficiency seems to remain a widespread problem in this population and justifies a large scale survey of iodine status.
Author Sedki, A.
Lekouch, N.
Bouglé, D.
Zaida, F.
Laroche, D.
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Cites_doi 10.1007/BF01954494
10.1111/j.1753-4887.2001.tb05512.x
10.1210/jcem-59-1-90
10.1385/BTER:79:2:121
10.1089/thy.2000.10.991
10.1007/BF03345821
10.1093/clinchem/34.3.474
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Keywords Morocco
iode
TSH
nouveau-né
Maroc
newborn
Iodine
Sang
Homme
Hormone adénohypophysaire
Endocrinopathie
Hypothyroïdie
Thyroïde pathologie
Nouveau né
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Snippet Une courte étude prospective de la fonction thyroïdienne du nouveau-né à terme (n = 90) a été réalisée dans une maternité de Marrakech (Maroc), en préliminaire...
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SubjectTerms Endocrinopathies
iode
Iodine
Maroc
Morocco
newborn
nouveau-né
Pathologie non tumorale. Résistance tissu cible. Tumeurs bénignes
Sciences biologiques et medicales
Sciences biologiques fondamentales et appliquees. Psychologie
Sciences medicales
Thyroïde. Axe thyroïdien (pathologie)
TSH
Vertebres: endocrinologie
Title TSH au cordon élevées au Maroc : hypothyroïdie iatrogène ?
URI https://dx.doi.org/10.1016/S0003-4266(06)72538-0
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