LP-211, a selective 5-HT 7 receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats

Gambling disorder is associated to an increased impulsivity, a high level of novelty-seeking and a dysregulation of the forebrain neurotransmission systems. However, the neurobiological mechanisms of this addictive disorder are not fully understood and no valid pharmacological approach has yet been...

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Bibliographic Details
Published in:	Synapse (New York, N.Y.) Vol. 71; no. 12
Main Authors:	Beaudet, G, Paizanis, E, Zoratto, F, Lacivita, E, Leopoldo, M, Freret, T, Laviola, G, Boulouard, M, Adriani, W
Format:	Journal Article
Language:	English
Published:	United States Wiley-Blackwell 01-12-2017
Subjects:	Analysis of Variance Animals Cognitive science Conditioning, Operant - drug effects Conditioning, Operant - physiology Humanities and Social Sciences Life Sciences Male Memory - drug effects Memory - physiology Motor Activity - drug effects Motor Activity - physiology Neuropsychological Tests Neuroscience Piperazines - pharmacology Psychology Psychotropic Drugs - pharmacology Random Allocation Rats, Wistar Receptors, Serotonin - metabolism Reward Risk-Taking Serotonin Receptor Agonists - pharmacology Space Perception - drug effects Space Perception - physiology probabilistic delivery task spatial memory curiosity drive novelty-seeking 5-HT7 receptors aryl-piperazines gambling behavior
Online Access:	Get full text
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