P292 Faecal calprotecin may be a good predictor of histologic remission in ulcerative colitis

• Published in: Journal of Crohn's and colitis Vol. 12; no. supplement_1; p. S248
• Main Authors: Knezevic Ivanovski, T, Knezevic Usaj, S, Svorcan, P, Nedeljkovic Protic, M
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 16-01-2018
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjx180.419

Abstract
Background
Fecal calprotectin (FCP) was shown as a good biomarker for diagnosis and assessment of disease severity, having a good correlation with endoscopic indices and clinical presentation. With development of validated histologic scores, such as Nancy index (NI) and Robarts’ index(RHI), the need to determine the relationship of histological activity with non-invasive biomarkers has arrised. Strong correlation between FCP and Geboes score were previously reported.1,2 The aim of this study was to compare the association of 3 histological scores with FCP and to establish the score with strongest correlation with FCP.
Methods
82 patients with UC from a single tertiary IBD Centre were enrolled in this prospective observational study. Endoscopic activity was evaluated by Mayo endoscopic sub-scores. For the assessment of histological activity three scores was used Geboes score, Nancy and Robarts’ score was used. Remission for Geboes score was defined as score lower than 3.1. Scores 0 and 1 are sings of remission in Nancy score. For Robarts score remission was defined as score lower than 6. Buhlmann rapid test for FCP was used with cut off level of 100 μg/g. Statistical analysis was carried out using SPSS 20.0 (Chicago, IL).
Results
38% (31/82) of patients were in endoscopic remission while 33% (27/82) achieved histological remission. Correlation was found between FCP and all of three scores with strongest correlation with Nancy score (p < 0.001, r = 0.538- Spearman correlation). Correlation with Robarts score (p < 0.001, r = 0.505- Spearman correlation) and Geboes (p < 0.001, r = 0.382- Spearman correlation) was slightly lower. Also there was a strong correlation between Geboes score and Nancy (p < 0.001, r = 0.599) and Robarts scores (p < 0.001, r = 0.707).
Conclusions
FCP showed the strongest correlation with Nancy histological score in the estimation of deep remission in UC patients. Further studies are needed to prove that FCP may be a good marker of histological remission as well
References
1. Ivanovski TK, Usaj SK, Gligorijevic, et al. Fecal calprotectin as suitable biomarker in evaluation of histological disease activity. JCC abstract book 2017.
2. Zittan E, Kelly OB, Kirsch R, et al. Low fecal calprotectin correlates with histological remission and mucosal healing in ulcerative colitis and colonic Crohn’s disease. Inflamm Bowel Dis, 623–30