Neuropsychopharmacological Effects of Leaves and Seeds Extracts of Datura fastuosa

• Published in: Biotechnology (Faisalābād, Pakistan) Vol. 3; no. 2; pp. 109 - 113
• Main Authors: ., Ange Antoine Abena, ., Landry M.Miguel, ., Alain Mouanga, ., Jean M. Ouamba, Sianard, DorotheeF, ., Marie H. Thiebolt, Hondi-assa, Theophile C., ., Martin Diatewa
• Format: Journal Article
• Language: English
• Published: 15-06-2004
• Subjects: Datura; Solanaceae
• ISSN: 1682-296X
• DOI: 10.3923/biotech.2004.109.113

Neuropsychopharmacological effects of aqueous extracts of leaves and seeds of Datura fastuosa (D. fastuosa), a solanaceae recently introduced in Congo as ornamental plant, were studied in rat and mice by oral administration using classical methods. Results revealed that extracts of D. fastuosa were well tolerated by rats. No mortality was observed until 3200 mg kg super(-1). The doses of 400 and 800 mg kg super(-1) of leaves and seeds extracts increased motor activity, reduced slightly the duration of barbituric sleeping, antagonized catalepsy and ptosis induced by haloperidol and the immobility induced by forced swimming. D. fastuosa exhibited analgesic effect in acetic acid test with tolerance phenomenon in the leaves but not in the seeds extracts. Only the leaves extract reduced rectal temperature, apomorphin hypothermia and increased water drinking. Those results showed that, at the low doses, D. fastuosa has some antidepressant profile.