Different rate of retinal degenerations in mice with two distinct mutations in the Mitf gene

Purpose The microphthalmia‐associated transcription factor (Mitf) gene is crucial for development of the retinal pigment epithelium (RPE) and photoreceptors. Loss of function mutations in this gene can cause ocular hypopigmentation, microphthalmia and blindness. Mice heterozygous for the Mitfmi‐wh/+...

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Bibliographic Details
Published in:	Acta ophthalmologica (Oxford, England) Vol. 97; no. S263
Main Authors:	Eysteinsson, Thor, Jónasdóttir, Ingunn, García‐Llorca, Andrea, Björg Gudmundsdóttir, Thorunn, Ögmundsdóttir, Margrét Helga, Steingrímsson, Eiríkur
Format:	Journal Article
Language:	English
Published:	Malden Wiley Subscription Services, Inc 01-12-2019
Subjects:	Animals Blindness Cornea Electroretinograms Electroretinography Epithelium Heterozygotes Ketamine Microphthalmia-associated transcription factor MITF gene Mutation Optical Coherence Tomography Phenotypes Photoreceptors Pigmentation Retina Retinal degeneration Retinal pigment epithelium Structure-function relationships Xylazine
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