Matrikines of Sea Cucumbers: Structure, Biological Activity and Mechanisms of Action

Matrikines (MKs), the products of enzymatic fragmentation of various extracellular matrix (ECM) proteins, regulate cellular activity by interacting with specific receptors. MKs affect cell growth, proliferation, and migration, can induce apoptosis and autophagy, and are also effectively used in biom...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 22; p. 12068
Main Authors:	Popov, Aleksandr, Kozlovskaya, Emma, Rutckova, Tatyana, Styshova, Olga, Makhankov, Vyacheslav, Vakhrushev, Aleksey, Hushpulian, Dmitry, Gazaryan, Irina, Son, Oksana, Tekutyeva, Ludmila
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 10-11-2024 MDPI
Subjects:	Amino acids Antioxidants Biological activity Chondroitin sulfate Chronic illnesses Heparan sulfate Molecular weight Nutrition Oxidative stress Peptides Proteins Review Tissue engineering
Online Access:	Get full text
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Summary:	Matrikines (MKs), the products of enzymatic fragmentation of various extracellular matrix (ECM) proteins, regulate cellular activity by interacting with specific receptors. MKs affect cell growth, proliferation, and migration, can induce apoptosis and autophagy, and are also effectively used in biomedicine and functional nutrition. Recently, there has been great interest in the structural features and biological activity of MKs from various sources. This review summarized and analyzed the results of modern research on MKs from sea cucumbers, primarily from trepang (MKT). Particular attention is paid to the analysis of the existing knowledge on the antioxidant, anti-inflammatory and adaptogenic activities of these MKs and the possible mechanisms of their protective action.
Bibliography:	These authors contributed equally to this work.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms252212068