Characteristics and outcomes of thymomas in L atin A merica: Results from over 10 years of experience ( CLICaP‐LATimus )

• Published in: Thoracic cancer Vol. 12; no. 9; pp. 1328 - 1335
• Main Authors: Martín, Claudio, Enrico, Diego, Mas, Luis, Patane, Ana Karina, Arrieta, Oscar, Soria, Tannia, Cardona, Andrés F., Ruiz‐Patiño, Alejandro, Ruiz, Rossana, Rioja, Patricia, Lozano, Sophia, Zatarain‐Barrón, Zyanya Lucia, Barrón, Feliciano, Puparelli, Carmen, Tsou, Florencia, Corassa, Marcelo P., Freitas, Helano C., Cordeiro de Lima, Vladmir Cláudio, Rojas, Leonardo, Ordóñez‐Reyes, Camila, Corrales, Luis, Sotelo, Carolina, Rodríguez, July, Ricaurte, Luisa, Ávila, Jenny, Archila, Pilar, Rosell, Rafael, Cuello, Mauricio, Remon, Jordi
• Format: Journal Article
• Language: English
• Published: Tianjin John Wiley & Sons, Inc 01-05-2021
• Subjects: Biopsy; Cancer therapies; Chemotherapy; Classification; Cohort analysis; Consortia; Dehydrogenases; Females; Lung cancer; Medical prognosis; Metastasis; Myasthenia gravis; Radiation therapy; Standard deviation; Statistical analysis; Survival analysis; Tumors
• DOI: 10.1111/1759-7714.13901
• EISSN: 1759-7714
• ISSN: 1759-7706

BackgroundThymomas are a group of rare neoplasms of the anterior mediastinum. The objective of this study was to describe the demographics, clinical characteristics and treatment approaches in Latin America.MethodsThis was a retrospective multicenter cohort study including patients with histologically proven thymomas diagnosed between 1997 and 2018. Demographics, clinicopathological characteristics and therapeutic outcomes were collected locally and analyzed in a centralized manner.ResultsA total of 135 patients were included. Median age at diagnosis was 53 years old (19–84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG performance score ranging from 0–1. A total of 47 patients (34.8%) had metastatic disease at diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgery was performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and 47 (34.8%) thymectomies. According to the Masaoka‐Koga system, overall survival (OS) at five‐years was 73.4%, 63.8% and 51%, at stages I–II, III–IVA and IVB, respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase (LDH) (≤373 IU/L) at baseline and myasthenia gravis concurrence showed significantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, high LDH levels (HR 2.8 [95% confidence interval [CI]: 1.1–7.8]; p = 0.036) at baseline and not performing a surgical resection (HR 4.1 [95% CI: 1.3–12.7]; p = 0.016) were significantly associated with increased risk of death.ConclusionsOur data provides the largest insight into the clinical characteristics and outcomes of patients with thymomas in Latin America. Survival in patients with thymomas continues to be very favorable, especially when subjected to adequate local control.