Structural and Functional Studies of the Metastatic Factors P‐Rex1 and P‐Rex2: Toward Small Molecule Inhibitor Development

Abstract only Phosphatidylinositol 3,4,5‐trisphosphate (PIP 3 )‐dependent Rac exchanger 1 (P‐Rex1) is a Rho guanine‐nucleotide exchange factor (RhoGEF) that regulates cytoskeletal rearrangement and cell motility and is linked to tumor metastasis. The P‐Rex family includes P‐Rex1 and P‐Rex2, which ar...

Full description

Bibliographic Details

Published in:	The FASEB journal Vol. 31; no. S1
Main Authors:	Sharma, Prateek, Davis, Ellen M., Cash, Jennifer, Tesmer, John J. G.
Format:	Journal Article
Language:	English
Published:	01-04-2017
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!