Development of a population pharmacokinetic (PPK) model of intravenous (IV) trastuzumab in patients with a variety of solid tumors to support dosing and treatment recommendations

Abstract only 2525 Background: The aim of this analysis was to develop a PPK model for IV trastuzumab (Herceptin), to assess the impact of patient covariates on PK, and perform simulations to support dosing recommendations. Methods: Serum trastuzumab concentration data (26,040 samples) from 1582 pat...

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Bibliographic Details

Published in:	Journal of clinical oncology Vol. 35; no. 15_suppl; p. 2525
Main Authors:	Kirschbrown, Whitney Paige, Quartino, Angelica Linnea, Li, Hanbin, Mangat, Ranvir, Wada, D Russell, Garg, Amit, Jin, Jin Y, Lum, Bert L.
Format:	Journal Article
Language:	English
Published:	20-05-2017
Online Access:	Get full text
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