CASE REPORT OF A CHILD DIAGNOSED WITH FIVE SEROTYPES / SEROGROUPS OF S. PNEUMONIAE

• Published in: Problems of infectious and parasitic diseases Vol. 50; no. 2; pp. 5 - 7
• Main Authors: Levterova, Viktoria, Simeonovski, Ivan, Brankova, Nadia, Ivanova, Magi, Philipova, Ivva, Malcheva, Mariya
• Format: Journal Article
• Language: English
• Published: National Center of Infectious and Parasitic Diseases 19-02-2023
• Subjects: nasopharyngeal carriage; PCR typing; Streptococcus pneumoniae
• ISSN: 0204-9155; 2815-2808
• DOI: 10.58395/pipd.v50i2.87

Streptococcus pneumoniae is one of the most common causes of widespread diseases. Pneumococci colonize asymptomatically the nasopharynx in children and could be responsible for severe, life-threatening illnesses such as pneumonia, sepsis and meningitis. The case report shows co-colonisation in two-year-old child vaccinated with the 10-valent pneumococcal conjugate vaccine (PCV-10) suffering from recurring catarrh and found to carry 5 serotypes S. pneumoniae. The strains have been detected and typed using molecular methods: real-time polymerase chain reaction (real-time PCR) and allelic hybridization. Monitoring S. pneumoniae colonization of human mucosa is crucial to reduce the likelihood of severe invasive pneumococcal diseases such as meningitis, pneumonia or otitis.