Cerebrospinal fluid tau, phospho‐tau 181 and β ‐amyloid 1−42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease
The aim of the present study was the quantitation of total tau protein ( τ T ), tau phosphorylated at threonine 181 ( τ P‐181 ) and β ‐amyloid 1−42 (A β 42) in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD) and controls....
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| Published in: | European journal of neurology Vol. 14; no. 2; pp. 168 - 173 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-02-2007
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| Abstract | The aim of the present study was the quantitation of total tau protein (
τ
T
), tau phosphorylated at threonine 181 (
τ
P‐181
) and
β
‐amyloid
1−42
(A
β
42) in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD) and controls. Double sandwich ELISAs (Innogenetics) were used for the measurements. Total tau was significantly increased in iNPH and highly increased in AD as compared with the control group, whilst A
β
42 was decreased in both diseases. CSF
τ
P−181
levels were significantly increased only in AD, but not in iNPH as compared with the controls. A cut‐off level for
τ
T
at 300 pg/ml, successfully discriminated AD from normal aging with a 95.8% specificity and 91% sensitivity; whilst the
τ
P‐181
/
τ
T
ratio (cut‐off value 0.169) was more specific (100%) but less sensitive (92.5%). For the discrimination of iNPH from AD
τ
T
achieved low specificity (77.8%) but high sensitivity (92.5%), whilst
τ
P‐181
(cut‐off value 47.4) was both sensitive and specific (88.7% and 86.7% respectively) for the discrimination of these disorders. The present study, despite being clinical, supports the notion that CSF
τ
P‐181
alone or in combination with
τ
T
may be a useful marker in the discrimination of iNPH from AD. |
|---|---|
| AbstractList | The aim of the present study was the quantitation of total tau protein (
τ
T
), tau phosphorylated at threonine 181 (
τ
P‐181
) and
β
‐amyloid
1−42
(A
β
42) in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD) and controls. Double sandwich ELISAs (Innogenetics) were used for the measurements. Total tau was significantly increased in iNPH and highly increased in AD as compared with the control group, whilst A
β
42 was decreased in both diseases. CSF
τ
P−181
levels were significantly increased only in AD, but not in iNPH as compared with the controls. A cut‐off level for
τ
T
at 300 pg/ml, successfully discriminated AD from normal aging with a 95.8% specificity and 91% sensitivity; whilst the
τ
P‐181
/
τ
T
ratio (cut‐off value 0.169) was more specific (100%) but less sensitive (92.5%). For the discrimination of iNPH from AD
τ
T
achieved low specificity (77.8%) but high sensitivity (92.5%), whilst
τ
P‐181
(cut‐off value 47.4) was both sensitive and specific (88.7% and 86.7% respectively) for the discrimination of these disorders. The present study, despite being clinical, supports the notion that CSF
τ
P‐181
alone or in combination with
τ
T
may be a useful marker in the discrimination of iNPH from AD. |
| Author | Paraskevas, G. P. Tzerakis, N. G. Seretis, A. Vassilopoulos, D. Sfagos, C. Kapaki, E. N. Kararizou, E. |
| Author_xml | – sequence: 1 givenname: E. N. surname: Kapaki fullname: Kapaki, E. N. – sequence: 2 givenname: G. P. surname: Paraskevas fullname: Paraskevas, G. P. – sequence: 3 givenname: N. G. surname: Tzerakis fullname: Tzerakis, N. G. – sequence: 4 givenname: C. surname: Sfagos fullname: Sfagos, C. – sequence: 5 givenname: A. surname: Seretis fullname: Seretis, A. – sequence: 6 givenname: E. surname: Kararizou fullname: Kararizou, E. – sequence: 7 givenname: D. surname: Vassilopoulos fullname: Vassilopoulos, D. |
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| Cites_doi | 10.1007/s00702-003-0075-x 10.1007/BF02815140 10.1016/S0197-4580(98)00022-0 10.1016/0022-3956(75)90026-6 10.1016/S1474-4422(03)00487-3 10.1016/S1474-4422(03)00530-1 10.1046/j.1471-4159.1997.68010430.x 10.1136/jnnp.71.3.401 10.1046/j.1468-1331.2003.00562.x 10.1212/WNL.34.7.939 10.1097/00001756-199712220-00022 10.1046/j.1440-1819.2000.00658.x 10.1055/s-2003-40733 10.1006/bbrc.1997.6908 10.1212/WNL.54.9.1875 10.1016/j.clineuro.2004.10.011 10.1016/S0304-3940(01)01556-7 10.1016/0022-510X(65)90016-X 10.1212/WNL.52.8.1555 10.1016/S0304-3940(00)01697-9 10.1016/S0967-5868(03)00079-1 10.1177/0891988705277549 10.1046/j.1471-4159.1999.0730443.x 10.1159/000008181 10.1136/jnnp.68.6.778 10.1097/00006123-200111000-00028 |
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| References | e_1_2_5_26_2 e_1_2_5_27_2 e_1_2_5_24_2 e_1_2_5_25_2 e_1_2_5_22_2 e_1_2_5_23_2 e_1_2_5_20_2 e_1_2_5_21_2 MacKhann G (e_1_2_5_12_2) 1984; 34 e_1_2_5_28_2 e_1_2_5_29_2 e_1_2_5_14_2 e_1_2_5_13_2 e_1_2_5_9_2 e_1_2_5_8_2 e_1_2_5_7_2 e_1_2_5_10_2 e_1_2_5_6_2 e_1_2_5_5_2 e_1_2_5_4_2 e_1_2_5_11_2 e_1_2_5_3_2 e_1_2_5_2_2 e_1_2_5_18_2 e_1_2_5_17_2 e_1_2_5_19_2 Walchenbach R (e_1_2_5_16_2) 2002; 72 Relkin N (e_1_2_5_15_2) 2005; 57 |
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| Snippet | The aim of the present study was the quantitation of total tau protein (
τ
T
), tau phosphorylated at threonine 181 (
τ
P‐181
) and
β
‐amyloid
1−42
(A
β
42) in... |
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| Title | Cerebrospinal fluid tau, phospho‐tau 181 and β ‐amyloid 1−42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease |
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