Structural and functional state of the erythrocytes, ligand forms of haemoglobin and content of molecules of middle mass in blood plasma of patients with schizophrenia disorders

• Published in: Bìologìčnì studìï Vol. 4; no. 1; pp. 15 - 26
• Main Authors: Dudok, K. P., Vlokh, I. J., Vlokh, R. O., Dudok, T. H., Fedorovych, A. M., Ilchishin, N. V., Shkavolyak, A. V., Sybirna, N. O.
• Format: Journal Article
• Language: English
• Published: Львівський національний університет імені Івана Франка 01-04-2010
• Subjects: conformation; electronic spectrums; erythrocyte; haemoglobin; ligand forms of haemoglobin; molecules of middle mass; schizophrenia
• DOI: 10.30970/sbi.0401.112
• EISSN: 2311-0783
• ISSN: 1996-4536

Stability of the erythrocyte membranes, content of the ligand forms of haemoglobin, parameters of the electronic spectra of haemoglobin complexes in patients with psychic disorders have been compared with the same indicators in healthy peoples. Patients with paranoid schizophrenia disorders, with some disorder symptoms and with psychic disorders caused by alcoholism, were under study. It has been shown that the erythrocytes of peoples with schizophrenia disorder manifest non-equivalent stability to haemolysis. Change in the ratio of haemoglobin ligand forms in patients with schizophrenia disorders have been found, in particular, the increase in the SHb and MetHb ratio, content of middle mass molecules in the blood plasma was detected. The method of optical spectroscopy has been proposed for studing of the haemoglobin conformation states in patients with schizophrenia disorders.