1021 Ductal carcinoma in situ (DCIS) of the male breast: Analysis of 23 cases

• Published in: European journal of cancer (1990) Vol. 31; p. S214
• Main Authors: Cutuli, B., Velten, M., Lacroze, M., Campana, F., Dilhuydy, J.M., Marchal, C., de la Fontan, B., Resbeut, M., Graic, Y., Tortocheaux, J., de Gislain, C., Moncho, V., Cuillere, J.C., N’guyen, T.D., Hery, M., Lesimple, T., Reme-Saumon, M., Lesaunier, F., Gamelin, E., Berlie, J.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-11-1995
• ISSN: 0959-8049; 1879-0852
• DOI: 10.1016/0959-8049(95)96269-J

From 1960 to 1990, 581 cases of male breast cancer (MBC) were reviewed in 19 Cancer Institutes in France. 23 (4%) were pure DCIS. The median age was 56.5 years (ext. 26–77). Five patients had less than 40 years (22%). Gynecomastia was found in 10 out of 23 patients (43%). Three had family history of B. C. According to TNM classification, we found 6 impalpable lesions (T0) discovered by serosanguineous nipple discharge, 7 T1, 6 T2, and 4 Tx.
The surgery consisted of 3 lumpectomies, 16 modified, 2 subcutaneous and 2 radical mastectomies. 16 patients had axillary dissections and 6 irradiation on the chest wall.
All cases were pure DCIS: in 14 the subtype was clearly identified: papillary (4), papillary intracystic (3), mixed papillary and cribriform (3), comedocarcinoma (2), cribriform (1), apocrine (1).
Three patients had local recurrences: two occurred in the patients initially treated by lumpectomy alone: the first was again a DCIS, but the second was an infiltrating carcinoma; this patient died by metastases. The last relapse occurred on the chest wall in a patient treated by mastectomy. One patient developed a contralateral DCIS. Two patients developed a lung and kidney cancer respectively.
In the literature the rate of DCIS in man varies from 0 to 16%. The serosanguineous nipple discharge seems a frequent symptom, especially in young men. The main histologic subtype is papillary (pure or intracystic). Mastectomy is the treatment of choice.