Myelitis Transverse in Sjögren's Syndrome and Systemic Lupus Erythematosus: Presentation of 3 Cases
Transverse myelitis is a rare focal inflammation of the spinal cord. Multiple etiologies have been identified including autoimmune diseases, mainly systemic lupus erythematosus and Sjögren’ syndrome. It can occur in an acute or subacute clinical onset, with the acute presentation having a worse prog...
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| Published in: | Reumatología clinica (Barcelona) Vol. 11; no. 1; pp. 41 - 44 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
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Elsevier España
01-01-2015
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| Abstract | Transverse myelitis is a rare focal inflammation of the spinal cord. Multiple etiologies have been identified including autoimmune diseases, mainly systemic lupus erythematosus and Sjögren’ syndrome. It can occur in an acute or subacute clinical onset, with the acute presentation having a worse prognosis. An early diagnosis and intensive treatment are important features recommended in these patients.
We present three cases with transverse myelitis associated with autoimmune diseases. We discuss different clinical manifestations, association with autoantobodies, radiologic findings, and therapeutic and prognostic issues.
La mielitis transversa es una inflamación focal poco frecuente de la médula espinal. Su etiología es múltiple y entre ellas se encuentran las enfermedades autoinmunes, incluyendo principalmente el lupus eritematoso sistémico y el síndrome de Sjögren. Su presentación clínica puede ser de forma aguda o subaguda, con peor pronóstico en la mielitis transversa aguda. Un diagnóstico precoz y tratamiento intensivo desde el inicio es de gran importancia en la evolución de este tipo de pacientes.
Presentamos 3 casos con mielitis transversa asociados a enfermedades autoinmunes y discutimos sus distintas manifestaciones clínicas, la asociación a autoanticuerpos, las imágenes radiológicas, el tratamiento y el pronóstico. |
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| AbstractList | Transverse myelitis is a rare focal inflammation of the spinal cord. Multiple etiologies have been identified including autoimmune diseases, mainly systemic lupus erythematosus and Sjögren’ syndrome. It can occur in an acute or subacute clinical onset, with the acute presentation having a worse prognosis. An early diagnosis and intensive treatment are important features recommended in these patients.
We present three cases with transverse myelitis associated with autoimmune diseases. We discuss different clinical manifestations, association with autoantobodies, radiologic findings, and therapeutic and prognostic issues.
La mielitis transversa es una inflamación focal poco frecuente de la médula espinal. Su etiología es múltiple y entre ellas se encuentran las enfermedades autoinmunes, incluyendo principalmente el lupus eritematoso sistémico y el síndrome de Sjögren. Su presentación clínica puede ser de forma aguda o subaguda, con peor pronóstico en la mielitis transversa aguda. Un diagnóstico precoz y tratamiento intensivo desde el inicio es de gran importancia en la evolución de este tipo de pacientes.
Presentamos 3 casos con mielitis transversa asociados a enfermedades autoinmunes y discutimos sus distintas manifestaciones clínicas, la asociación a autoanticuerpos, las imágenes radiológicas, el tratamiento y el pronóstico. |
| Author | García Guijo, Carmen Girón Úbeda, Juan Cardiel Rios, Mario H. Pérez Venegas, José Javier Menor Almagro, Raúl Ruiz Tudela, María del Mar |
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| Cites_doi | 10.1016/j.autrev.2009.12.007 10.1212/WNL.31.8.966 10.2165/00003495-200464020-00001 10.1212/01.WNL.0000101715.32569.1A 10.1212/WNL.59.4.499 10.1136/ard.59.2.120 10.1007/s100720100038 10.1016/j.semarthrit.2008.09.002 10.1097/01.md.0000141099.53742.16 |
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| Copyright | 2013 Elsevier España, S.L.U. |
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| DocumentTitleAlternate | Mielitis transversa en síndrome de Sjögren y lupus eritematoso sistémico: presentación de 3 casos |
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| Keywords | Systemic lupus erythematosus Sjögren's syndrome Síndrome de Sjögren Transverse myelitis Mielitis transversa Lupus eritematoso sistémico |
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| References_xml | – volume: 64 start-page: 123 year: 2004 end-page: 132 ident: bib0020 article-title: Myelopathy in Sjögren’ syndrome. Role of nonsteroidal immunosuppressants publication-title: Drugs contributor: fullname: Román – volume: 62 start-page: 147 year: 2004 end-page: 149 ident: bib0065 article-title: Recurrent transverse myelitis associates with anti-Ro (SSA) autoantibodies publication-title: Neurology contributor: fullname: Mahoney – volume: 25 start-page: 467 year: 1998 end-page: 473 ident: bib0045 article-title: Acute transverse myelopathy in systemic lupus erythematosus: clinical presentation, treatment, and outcome publication-title: J Rheumatol contributor: fullname: Wong – volume: 22 start-page: S69 year: 2001 end-page: S73 ident: bib0060 article-title: Diagnosis and differential diagnosis of acute transverse myelopathy. 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The role of neuroradiological investigations and review of the literature publication-title: Neurol Sci doi: 10.1007/s100720100038 contributor: fullname: Scotti – volume: 30 start-page: 208 year: 2012 ident: 10.1016/j.reumae.2014.03.021_bib0075 article-title: Rituximab in central nervous system manifestations of patients with primary Sjögren's syndrome: results from the AIR registry publication-title: Clin Exp Rheumatol contributor: fullname: Mekinian – volume: 39 start-page: 246 year: 2010 ident: 10.1016/j.reumae.2014.03.021_bib0070 article-title: Transverse myelitis affecting more than 4 spinal segments associated with lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2008.09.002 contributor: fullname: Espinosa – volume: 83 start-page: 280 year: 2004 ident: 10.1016/j.reumae.2014.03.021_bib0055 article-title: Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients publication-title: Medicine (Baltimore) doi: 10.1097/01.md.0000141099.53742.16 contributor: fullname: Delalande |
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| SubjectTerms | Lupus eritematoso sistémico Mielitis transversa Sjögren's syndrome Systemic lupus erythematosus Síndrome de Sjögren Transverse myelitis |
| Title | Myelitis Transverse in Sjögren's Syndrome and Systemic Lupus Erythematosus: Presentation of 3 Cases |
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