Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice

Aging and dyslipidemia are processes which can lead to deleterious consequences to renal function. Therefore, the aim of this study was to determine the effects of both hypercholesterolemia and aging on renal function in mice. Male hypercholesterolemic apolipoprotein E-deficient mice (ApoE, n = 13)...

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Bibliographic Details
Published in:	Lipids in health and disease Vol. 10; no. 1; p. 220
Main Authors:	Balarini, Camille M, Oliveira, Mariana Zt, Pereira, Thiago Mc, Silva, Nyam F, Vasquez, Elisardo C, Meyrelles, Silvana S, Gava, Agata L
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 26-11-2011 BioMed Central BMC
Subjects:	Age Factors Aging Animals Apolipoproteins Apolipoproteins E - deficiency Atherosclerosis Cholesterol Collagen Colleges & universities Complications and side effects Diet Fibrosis Gene Expression Genetic aspects Glomerular Filtration Rate Health sciences Hypercholesterolemia Hypercholesterolemia - complications Hypercholesterolemia - physiopathology Kidney - enzymology Kidney - pathology Kidney - physiopathology Kidney failure Kidney Tubules - pathology Kidneys Male Mice Mice, Inbred C57BL Mortality Nitric Oxide Synthase Type I - genetics Nitric Oxide Synthase Type I - metabolism Physiological aspects Proteins Renal Function Risk factors Rodents Science Statistical analysis Supervision Urea - blood Brazil
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