Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations

IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel diseases. Here we investigated whether polymorphisms i...

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Bibliographic Details
Published in:	Journal of medical genetics Vol. 45; no. 6; p. 362
Main Authors:	Kristjansdottir, G, Sandling, J K, Bonetti, A, Roos, I M, Milani, L, Wang, C, Gustafsdottir, S M, Sigurdsson, S, Lundmark, A, Tienari, P J, Koivisto, K, Elovaara, I, Pirttilä, T, Reunanen, M, Peltonen, L, Saarela, J, Hillert, J, Olsson, T, Landegren, U, Alcina, A, Fernández, O, Leyva, L, Guerrero, M, Lucas, M, Izquierdo, G, Matesanz, F, Syvänen, A-C
Format:	Journal Article
Language:	English
Published:	England 01-06-2008
Subjects:	Case-Control Studies Cohort Studies European Continental Ancestry Group - genetics Female Finland Genetic Predisposition to Disease - genetics Haplotypes Humans Interferon Regulatory Factors - genetics Linkage Disequilibrium - genetics Male Multiple Sclerosis - genetics Mutation - genetics Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Sp1 Transcription Factor - metabolism Spain Sweden Sweden Finland Spain
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