Detection of quantitative trait loci for growth and fatness in pigs

• Published in: Genetics selection evolution (Paris) Vol. 33; no. 3; pp. 289 - 309
• Main Authors: Bidanel, J.P. (Institut National de la Recherche Agronomique, Jouy en Josas (France). Centre de Jouy, Genetique Quantitative et Appliquee), Milan, D, Iannuccelli, N, Amigues, Y, Boscher, M.Y, Bourgeois, F, Caritez, J.C, Gruand, J, Le Roy, P, Lagant, H, Quintanilla, R, Renard, C, Gellin, J, Ollivier, L, Chevalet, C
• Format: Journal Article
• Language: English
• Published: Les Ulis EDP Sciences 15-05-2001; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Adipose Tissue - growth & development; ADIPOSE TISSUES; Alleles; Animal productions; Animals; Biological and medical sciences; Body Weight; CARTE GENETIQUE; CERDO; chromosome 1; chromosome 10; chromosome 11; chromosome 13; chromosome 14; chromosome 16; chromosome 18; chromosome 2; chromosome 3; chromosome 4; chromosome 5; chromosome 6; chromosome 7; chromosome 8; Chromosome Mapping; Classical genetics, quantitative genetics, hybrids; CRECIMIENTO; CROISSANCE; Data Collection; fatness; Female; Fundamental and applied biological sciences. Psychology; gene mapping; Genes; Genetic aspects; Genetic Linkage; GENETIC MAPS; Genetic Markers; GENETICA CUANTITATIVA; Genetics of eukaryotes. Biological and molecular evolution; GENETIQUE QUANTITATIVE; Genotype; GROWTH; Inbreeding; Life Sciences; Likelihood Functions; LOCI; LOCUS; Male; MAPAS GENETICOS; Models, Genetic; Multifactorial Inheritance; Pedigree; Physiological aspects; pig; Polymorphism, Genetic; PORCIN; QUANTITATIVE GENETICS; Quantitative trait loci; quantitative trait locus; Quantitative Trait, Heritable; SWINE; Swine - genetics; Swine - growth & development; TEJIDO ADIPOSO; Terrestrial animal productions; TISSU ADIPEUX; Vertebrata; Vertebrates; France; Genetic mapping; Farming animal; Adipose tissue; Genetic marker; Growth rate; Quantitative character; Experimental study; Fat mass; Pig; Quantitative genetics; Vertebrata; Meat animals; Mammalia; Gene; Meat production; Artiodactyla; Animal production; Ungulata; PIGS; QTL; FATNESS; GENETIC MAPS; GROWTH
• ISSN: 0999-193X; 1297-9686; 1297-9686
• DOI: 10.1186/1297-9686-33-3-289

A quantitative trait locus (QTL) analysis of growth and fatness data from a three-generation experimental cross between Meishan (MS) and Large White (LW) pig breeds is presented. Six boars and 23 F1 sows, the progeny of six LW boars and six MS sows, produced 530 F2 males and 573 F2 females. Nine growth traits, i.e. body weight at birth and at 3, 10, 13, 17 and 22 weeks of age, average daily gain from birth to 3 weeks, from 3 to 10 weeks and from 10 to 22 weeks of age, as well as backfat thickness at 13, 17 and 22 weeks of age and at 40 and 60 kg live weight were analysed. Animals were typed for a total of 137 markers covering the entire porcine genome. Analyses were performed using two interval mapping methods: a line-cross (LC) regression method where founder lines were assumed to be fixed for different QTL alleles and a half-/full-sib (HFS) maximum likelihood method where allele substitution effects were estimated within each half-/full-sib family. Both methods revealed highly significant gene effects for growth on chromosomes 1, 4 and 7 and for backfat thickness on chromosomes 1, 4, 5, 7 and X, and significant gene effects on chromosome 6 for growth and backfat thickness. Suggestive QTLs were also revealed by both methods on chromosomes 2 and 3 for growth and 2 for backfat thickness. Significant gene effects were detected for growth on chromosomes 11, 13, 14, 16 and 18 and for backfat thickness on chromosome 8, 10, 13 and 14. LW alleles were associated with high growth rate and low backfat thickness, except for those of chromosome 7 and to a lesser extent early-growth alleles on chromosomes 1 and 2 and backfat thickness alleles on chromosome 6