Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium

Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium

The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this...

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Published in:BMC neuroscience Vol. 13; no. 1; p. 134
Main Authors: Cunha, Carla, Hort, Yvonne, Shine, John, Doyle, Kharen L
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 31-10-2012
BioMed Central
BMC
Subjects:
Adult stem cells
Analysis
Animals
Apoptosis
Apoptosis - radiation effects
Basic Helix-Loop-Helix Transcription Factors - biosynthesis
Cell Movement - radiation effects
Cell Proliferation - radiation effects
Design
Epithelial cells
Eye Proteins - biosynthesis
Health aspects
Homeodomain Proteins - biosynthesis
Irradiation
Male
Mice
Mice, Inbred C57BL
Morphology (Animals)
Neuroepithelial Cells - cytology
Neuroepithelial Cells - radiation effects
Neurogenesis - radiation effects
Olfactory Bulb - cytology
Olfactory Bulb - radiation effects
Olfactory Marker Protein - biosynthesis
Olfactory nerve
Olfactory neuroepithelium
Olfactory Receptor Neurons - cytology
Olfactory Receptor Neurons - radiation effects
Paired Box Transcription Factors - biosynthesis
PAX6 Transcription Factor
Physiological aspects
Proliferation
Repressor Proteins - biosynthesis
Smell - radiation effects
Statistical analysis
Stem cells
Stem Cells - radiation effects
Studies
Time Factors
X-ray irradiation
X-rays
Australia
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Abstract The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.
AbstractList Background: The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. Results: We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. Conclusions: We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.
Background The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. Results We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. Conclusions We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells. Keywords: Olfactory neuroepithelium, X-ray irradiation, Proliferation, Apoptosis, Adult stem cells
The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.
Doc number: 134 Abstract Background: The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. Results: We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo . Conclusions: We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.
The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.
Abstract Background The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. Results We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. Conclusions We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.
ArticleNumber 134
Audience Academic
Author Doyle, Kharen L
Hort, Yvonne
Cunha, Carla
Shine, John
AuthorAffiliation 1 Neuroscience Research Program, Garvan Institute of Medical Research, Sydney, Australia
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  givenname: Carla
  surname: Cunha
  fullname: Cunha, Carla
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  surname: Hort
  fullname: Hort, Yvonne
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  surname: Shine
  fullname: Shine, John
– sequence: 4
  givenname: Kharen L
  surname: Doyle
  fullname: Doyle, Kharen L
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23113950$$D View this record in MEDLINE/PubMed
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SSID ssj0017842
Score 2.0798118
Snippet The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to...
Background The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The...
Doc number: 134 Abstract Background: The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the...
Background: The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The...
BACKGROUND: The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The...
Abstract Background The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs....
SourceID doaj
pubmedcentral
biomedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 134
SubjectTerms Adult stem cells
Analysis
Animals
Apoptosis
Apoptosis - radiation effects
Basic Helix-Loop-Helix Transcription Factors - biosynthesis
Cell Movement - radiation effects
Cell Proliferation - radiation effects
Design
Epithelial cells
Eye Proteins - biosynthesis
Health aspects
Homeodomain Proteins - biosynthesis
Irradiation
Male
Mice
Mice, Inbred C57BL
Morphology (Animals)
Neuroepithelial Cells - cytology
Neuroepithelial Cells - radiation effects
Neurogenesis - radiation effects
Olfactory Bulb - cytology
Olfactory Bulb - radiation effects
Olfactory Marker Protein - biosynthesis
Olfactory nerve
Olfactory neuroepithelium
Olfactory Receptor Neurons - cytology
Olfactory Receptor Neurons - radiation effects
Paired Box Transcription Factors - biosynthesis
PAX6 Transcription Factor
Physiological aspects
Proliferation
Repressor Proteins - biosynthesis
Smell - radiation effects
Statistical analysis
Stem cells
Stem Cells - radiation effects
Studies
Time Factors
X-ray irradiation
X-rays
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Title Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium
URI https://www.ncbi.nlm.nih.gov/pubmed/23113950
https://www.proquest.com/docview/1266211273
https://search.proquest.com/docview/1272730237
http://dx.doi.org/10.1186/1471-2202-13-134
https://pubmed.ncbi.nlm.nih.gov/PMC3536589
https://doaj.org/article/c987ddc8b1914a9dac016464fd7bdaf4
Volume 13
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