Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin

Mixed Lineage Leukemia 1 (MLL1) is a mammalian ortholog of the Drosophila Trithorax. In Drosophila, Trithorax complexes transmit the memory of active genes to daughter cells through interactions with Trithorax Response Elements (TREs). However, despite their functional importance, nothing is known a...

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Bibliographic Details
Published in:	BMC genomics Vol. 14; no. 1; p. 927
Main Authors:	Bina, Minou, Wyss, Phillip, Novorolsky, Elise, Zulkelfi, Noorfatin, Xue, Jing, Price, Randi, Fay, Matthew, Gutmann, Zach, Fogler, Brian, Wang, Daidong
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 28-12-2013 BioMed Central
Subjects:	Base Sequence Binding proteins Cell division Chromatin Chromatin - genetics Chromatin - metabolism CpG Islands Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA methylation DNA sequencing Drosophila Enzymes Gene expression Genome, Human Genomes Genomics Histone-Lysine N-Methyltransferase Humans Insects Methods Mitosis Mitosis - physiology Molecular Sequence Data Mutation Myeloid-Lymphoid Leukemia Protein - metabolism Nucleotide Motifs Nucleotide sequencing Open Reading Frames Promoter Regions, Genetic Promoters (Genetics) Protein Binding Protein Interaction Domains and Motifs Protein Interaction Mapping Proteins Random variables RNA polymerase RNA Polymerase II - genetics
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