The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 107; no. 3; pp. 433 - 436
• Main Authors: Mario, Débora Alves Nunes, Denardi, Laura Bedin, Bandeira, Laíssa Arévalo, Antunes, Milene Silva, Santurio, Janio Morais, Severo, Luiz Carlos, Alves, Sydney Hartz
• Format: Journal Article
• Language: English
• Published: Brazil Fundação Oswaldo Cruz, Fiocruz 01-05-2012; Instituto Oswaldo Cruz, Ministério da Saúde; Fundação Oswaldo Cruz (FIOCRUZ)
• Subjects: Amphotericin B; Amphotericin B - pharmacology; Anidulafungin; Antifungal agents; Antifungal Agents - pharmacology; antifungal drug resistance; azoles; Candida; Candida glabrata; Candida glabrata - drug effects; Candida glabrata - echinocandins - antifungal drug resistance; Candida glabrata - isolation & purification; Caspofungin; Cross-resistance; Drug Resistance, Fungal - drug effects; echinocandins; Echinocandins - pharmacology; fluconazole; Fluconazole - pharmacology; Humans; Lipopeptides - pharmacology; Micafungin; Microbial Sensitivity Tests; PARASITOLOGY; polyenes; Pyrimidines - pharmacology; Triazoles - pharmacology; TROPICAL MEDICINE; Voriconazole; echinocandins; antifungal drug resistance; Candida glabrata
• ISSN: 1678-8060; 0074-0276; 1678-8060; 0074-0276
• DOI: 10.1590/s0074-02762012000300022

The extensive use of azole antifungal agents has promoted the
resistance of Candida spp to these drugs. Candida glabrata is a
problematic yeast because it presents a high degree of primary or
secondary resistance to fluconazole. In Brazil, C. glabrata has been
less studied than other species. In this paper, we compared the
activity of three major classes of antifungal agents (azoles,
echinocandins and polyenes) against fluconazole-susceptible (FS) and
fluconazole-resistant (FR) C. glabrata strains. Cross-resistance
between fluconazole and voriconazole was remarkable. Among the
antifungal agents, the echinocandins were the most effective against FS
and FR C. glabrata and micafungin showed the lowest minimal inhibitory
concentrations.