Apoptosis and frequency of total and effector CD8+ T lymphocytes from cutaneous leishmaniasis patients during antimonial therapy

Leishmaniasis is an important parasitic disease affecting millions worldwide. Human cutaneous leishmaniasis (CL) is endemic in Rio de Janeiro, Brazil, where is caused by Leishmania braziliensis. The adaptive immune response is accountable for the healing of CL and despite of key role of CD8+ T cells...

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Bibliographic Details
Published in:	BMC infectious diseases Vol. 15; no. 1; p. 74
Main Authors:	Ferraz, Raquel, Cunha, Clarissa F, Gomes-Silva, Adriano, Schubach, Armando O, Pimentel, Maria Inês F, Lyra, Marcelo Rosandiski, Mendonça, Sergio Cf, Valete-Rosalino, Cláudia M, Da-Cruz, Alda Maria, Bertho, Álvaro Luiz
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 19-02-2015 BioMed Central
Subjects:	Adult Analysis Antigens Antigens, Protozoan - immunology Antiprotozoal Agents - therapeutic use Apoptosis - drug effects Apoptosis - immunology Brazil Care and treatment CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - physiology Cohort Studies Female Flow Cytometry Humans Immune response Leishmania braziliensis - drug effects Leishmania braziliensis - immunology Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - immunology Male Meglumine - therapeutic use Middle Aged Organometallic Compounds - therapeutic use Parasitic diseases Physiological aspects Young Adult Brazil
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