Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model

Mitochondrial dysfunction is a hallmark of neurodegenerative diseases including Alzheimer's disease (AD), with morphological and functional abnormalities limiting the electron transport chain and ATP production. A contributing factor of mitochondrial abnormalities is loss of nicotinamide adenin...

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Bibliographic Details
Published in:	BMC neurology Vol. 15; no. 1; p. 19
Main Authors:	Long, Aaron N, Owens, Katrina, Schlappal, Anna E, Kristian, Tibor, Fishman, Paul S, Schuh, Rosemary A
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 01-03-2015 BioMed Central
Subjects:	Advertising executives Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Analysis Animals Brain - metabolism Brain - pathology Care and treatment Cell death Female Male Mice Mice, Transgenic Mitochondria - pathology NAD - metabolism Neurodegenerative Diseases - physiopathology Neurons Nicotinamide Mononucleotide - pharmacology Oxygen Consumption - physiology Prevention
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